Voltage-Sensitive Ion Channels in Human B Lymphocytes
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Ion channels are protein pores that provide for the rapid movement of ions across cell membranes. Such channels control the transmembrane flow of ions by opening or closing in response to appropriate stimuli (a property referred to as gating) and by allowing only specific types of ions to pass through (a property referred to as selectivity). Although ion channels have been studied in nerve and muscle for many years (see 1 for a review), it is only since the development of the patch-clamp technique (2) that they have been detected in a variety of other tissues and systems. In the immune system such diverse cell types as T lymphocytes, B lymphocytes, macrophages, neutrophils, hybridomas, and natural killer cells express an assortment of channels (reviewed in 3).
KeywordsOutward Current External Solution Tail Current Single Channel Conductance Channel Density
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