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Signal Transduction via the B Cell Antigen Receptor: Involvement of a G Protein and Regulation of Signaling

  • Anthony L. DeFranco
  • Michael R. Gold

Abstract

The antigen receptor on B lymphocytes plays critical roles in B cell development and B cell activation. Antigen or anti-immunoglobulin stimulation of membrane IgM (mIgM) on immature B cells, such as those found in neonatal mice, results in the functional inactivation of the B cell1. This response, referred to as “clonal anergy” by Nossal and colleagues, would be expected to inactivate B cells with mIgM specific for autoantigens in the environment of the developing B cell, and hence may play a role in the generation of B cell tolerance. Stimulation of the antigen receptor on a mature B cell, on the other hand, contributes to the activation of that cell to proliferate and differentiate into antibody secreting cells2,3. In the case of the immature B cell,the antigen receptor must be acting as a signal transducing receptor, since this response can be seen at the single cell level4. In the case of B cell activation, mlg appears to play a dual role: it can serve,as a very efficient means of taking up antigen for presentation to helper T cells5–7. Additionaby, mlg can act as a signal transducing receptor, as revealed by the striking effects of anti-immunoglobulin antibodies on resting mature B cells8.

Keywords

Cholera Toxin Phorbol Ester Pertussis Toxin Inositol Phosphate Phorbol Myristate Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Anthony L. DeFranco
    • 1
  • Michael R. Gold
    • 1
  1. 1.Departments of Microbiology and Immunology and Biochemistry and BiophysicsUniversity of California, San FranciscoSan FranciscoUSA

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