Transcriptional Regulation of Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes

  • Skye McDougall
  • Suzanne Eaton
  • Craig L. Peterson
  • Kathryn Calame


Transcription of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) beta chain genes is controlled in a tissue and developmental stage specific manner (Calame, 1985; Kronenberg et al., 1986). We are studying the DNA sequence elements and cellular proteins which regulate transcription of these two important gene families. Early in B-cell ontogeny IgH transcription is activated as a result of VDJ joining which brings a transcriptional enhancer within functional proximity of the rearranged promoter (Mercola et al., 1983; Banerji et al., 1983; Gilles et al., 1983; Neuberger, 1983; Wang and Calame, 1985). Similar gene rearrangements occur in the beta chain locus during T cell ontogeny; however, the elements responsible for regulation of TCR beta genes have not been well defined.


Immunoglobulin Heavy Chain Transcriptional Enhancer Immunoglobulin Heavy Chain Gene Heavy Chain Promoter Beta Chain Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Skye McDougall
    • 1
  • Suzanne Eaton
    • 2
  • Craig L. Peterson
    • 2
  • Kathryn Calame
    • 3
  1. 1.Laboratory of Biomedical and Environmental ScienceUCLALos AngelesUSA
  2. 2.Department of Biochemistry and BiophysicsUCSFSan FranciscoUSA
  3. 3.Department of Microbiology ColumbiaUniversity College of Physicians and SurgeonsNew YorkUSA

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