Abstract
Transcription of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) beta chain genes is controlled in a tissue and developmental stage specific manner (Calame, 1985; Kronenberg et al., 1986). We are studying the DNA sequence elements and cellular proteins which regulate transcription of these two important gene families. Early in B-cell ontogeny IgH transcription is activated as a result of VDJ joining which brings a transcriptional enhancer within functional proximity of the rearranged promoter (Mercola et al., 1983; Banerji et al., 1983; Gilles et al., 1983; Neuberger, 1983; Wang and Calame, 1985). Similar gene rearrangements occur in the beta chain locus during T cell ontogeny; however, the elements responsible for regulation of TCR beta genes have not been well defined.
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McDougall, S., Eaton, S., Peterson, C.L., Calame, K. (1989). Transcriptional Regulation of Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes. In: Gupta, S., Paul, W.E. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5803-0_10
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DOI: https://doi.org/10.1007/978-1-4757-5803-0_10
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