Transcriptional Regulation of Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes
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Transcription of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) beta chain genes is controlled in a tissue and developmental stage specific manner (Calame, 1985; Kronenberg et al., 1986). We are studying the DNA sequence elements and cellular proteins which regulate transcription of these two important gene families. Early in B-cell ontogeny IgH transcription is activated as a result of VDJ joining which brings a transcriptional enhancer within functional proximity of the rearranged promoter (Mercola et al., 1983; Banerji et al., 1983; Gilles et al., 1983; Neuberger, 1983; Wang and Calame, 1985). Similar gene rearrangements occur in the beta chain locus during T cell ontogeny; however, the elements responsible for regulation of TCR beta genes have not been well defined.
KeywordsImmunoglobulin Heavy Chain Transcriptional Enhancer Immunoglobulin Heavy Chain Gene Heavy Chain Promoter Beta Chain Gene
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