• I. Roberts


Worldwide, many millions of people are treated each year for severe head injury. A substantial proportion die, and many more are permanently disabled [1]. Road traffic crashes alone account for an estimated five million head injuries each year [2]. Reliable assessment of the net benefits and hazards of various interventions for the treatment and rehabilitation of head injuries could be of considerable public health importance.


Head Injury Severe Head Injury Moderate Bias Acute Spinal Cord Injury High Dose Methylprednisolone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Murray CIL, Lopez AD (1996) Global health statistics: a compendium of incidence, prevalence and mortality estimates for over 200 conditions. Harvard University Press, BostonGoogle Scholar
  2. 2.
    Murray CJL, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 349: 1498–1504PubMedCrossRefGoogle Scholar
  3. 3.
    Peto R, Collins R, Gray R (1995) Large-scale randomised evidence: large simple trials and overviews of trials. J Clin Epidemiol 48: 23–40PubMedCrossRefGoogle Scholar
  4. 4.
    Dickinson K, Bunn F, Wentz R, Edwards P, Roberts I (2000) Size and quality of randomised controlled trials in head injury: review of published studies. Br Med J 320: 1308–1311CrossRefGoogle Scholar
  5. 5.
    Task Force of the American Association of Neurological Surgeons and Joint Section in Neurotrauma and Critical Care (1995) Guidelines for the management of severe head injury. Brain Trauma Foundation, New YorkGoogle Scholar
  6. 6.
    Jeevaratnum DR, Menon DK (1996) Survey of intensive care of severely head injured patients in the United Kingdom. Br Med J 312: 944–947CrossRefGoogle Scholar
  7. 7.
    Matta B, Menon D (1996) Severe head injury in the United Kingdom and Ireland: A survey of practice and implications for management. Crit Care Med 24: 1743–1748PubMedCrossRefGoogle Scholar
  8. 8.
    Alderson P, Roberts I (1997) Corticosteroids in acute traumatic brain injury: a systematic review of randomised trials. Br Med J 314: 1855–1859CrossRefGoogle Scholar
  9. 9.
    Bracken MB (2001) Pharmacological interventions for acute spinal cord injury. Cochrane Database Syst Rev: CD001046Google Scholar
  10. 10.
    Hall ED (1985) High dose glucocorticoid treatment improves neurological recovery in head-injured mice. J Neurosurg 62: 882–887PubMedCrossRefGoogle Scholar
  11. 11.
    Giannotta SL, Weiss MH, Apuzzo MLJ, Martin E (1984) High dose glucocorticoids in the management of severe head injury. Neurosurgery 15: 497–501PubMedCrossRefGoogle Scholar
  12. 12.
    Stubbs DF, Stiger TR, Harris WR (1989) Multinational controlled trial of high-dose methylprednisolone in moderately severe head injury. In: Capildeo R (ed) Steroids in Diseases of the Central Nervous System. John Wiley & Sons, Chichester, pp 163–168Google Scholar
  13. 13.
    Teasdale G (1991) The treatment of head trauma: implications for the future. J Neurotrauma 8 (suppl 1): 53–60Google Scholar
  14. 14.
    CRASH: Corticosteroid randomization after significant head injury. At:

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • I. Roberts

There are no affiliations available

Personalised recommendations