Acidemia: Good, Bad or Inconsequential?

  • J. A. Kellum
  • M. Song
  • S. Subramanian


Despite significant advances in the understanding of cellular physiology and acid-base chemistry, and despite progress in the treatment of acid-base disorders, a central clinical question remains unanswered: Is acidemia harmful? To address this question we will consider both theory and evidence. Acid-base theory is important because it impacts greatly on the interpretation of the limited clinical, epidemiologic, and experimental evidence. It is also important because most clinicians fail to understand or apply basic physical-chemical principles. This said, let us first review the basics of acid-base chemistry.


Metabolic Acidosis Lactic Acidosis Respir Crit Hydroxyethyl Starch Standard Base Excess 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • J. A. Kellum
  • M. Song
  • S. Subramanian

There are no affiliations available

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