Antibiotics by Continuous Infusion: Time for Re-evaluation?
Severe sepsis and septic shock account for 15–20% of intensive care unit (ICU) admissions and when associated with multi-organ dysfunction there is a 55% mortality . Surgical evacuation of any focus of infection should be undertaken where possible, however, the mainstay of treatment is antibiotic therapy. In recent years there have been considerable advances in the support of these patients with emphasis being placed on early, adequate volume resuscitation , administration of stress-dose corticosteroids , immunonutrition , and, more recently, manipulation of coagulation pathways . However, the way in which antibiotics are administered has remained largely unchanged since the 1940s. At a time when many standard therapies are being re-evaluated we should ask the question ‘Are we using antibiotics to their greatest potential?’
KeywordsSevere Sepsis Continuous Infusion Antimicrob Agent Intermittent Infusion Intermittent Bolus
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