The Prevention of Invasive Candida Infection in Critically Ill Surgical Patients

  • S. L. Sylvester
  • P. Lipsett


Over the past three decades, the significant morbidity and mortality associated with candidemia and invasive candidiasis have been well established. Technological and scientific advancement has led to an increase in the incidence of serious Candida infections. With the introduction of the azoles and more recently with the development of the echinocandin class of antifungals, our ability to treat these infections has improved; however, our ability to diagnose these infections in a timely fashion remains limited, and patient outcomes remain poor. Antifungal prophylaxis has emerged as a method to attempt to decrease the occurrence of these serious infections in selected high-risk patient populations. The role of antifungal prophylaxis is well established in bone marrow transplant recipients [1, 2]. In this chapter, we will review the role of antifungal prophylaxis in the surgical patient, with particular attention to the prevention of candidemia and invasive candidiasis in surgical intensive care unit (ICU) patients and abdominal organ transplant recipients.


Transplant Recipient Candida Species Invasive Fungal Infection Invasive Candidiasis Liver Transplant Recipient 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • S. L. Sylvester
  • P. Lipsett

There are no affiliations available

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