Myocardial Ischemia-reperfusion Injury: Role of the Peroxynitrite-poly(ADP-ribose) Polymerase Pathway

  • C. Szabó
  • L. Liaudet


The enzyme poly (ADP-ribose) polymerase (PARP) — also termed poly (ADP-ribose) synthetase (PARS) and poly (ADP-ribose) transferase (pPADPRT) — is an abundant nuclear protein present throughout the phylogenetic spectrum. The precise physiologic roles of PARP remain undefined; its traditional role as a DNA-repair enzyme has been questioned by recent studies. PARP plays diverse roles, participating in DNA repair, chromatin relaxation, cell differentiation, DNA replication, transcriptional regulation, control of cell cycle, p53 expression and apoptosis, and transformation [1].


Neutrophil Infiltration PARP Inhibitor PARP Cleavage PARP Activation Myocardial Reperfusion Injury 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • C. Szabó
  • L. Liaudet

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