Ischemia-reperfusion and Acute Apoptotic Cell Death

  • B. S. Abella
  • L. B. Becker


Ischemia, reperfusion, and apoptosis are vital physiological processes that demonstrate fantastic complexity. These processes have stimulated much interest, and even controversy, in part due to the important role they play in determining cell injury and cell death. Both basic scientists and clinicians understand the importance of elucidating these mechanisms. In this chapter, we will discuss the importance of ischemia in human disease, explore the events of reperfusion that may contribute to cell injury following ischemia, review the primary mechanisms of apoptosis, and finally speculate on the mechanisms that link ischemia-reperfusion (I/R) and acute apoptosis.


Infarct Size Systemic Inflammatory Response Syndrome Reperfusion Injury Cereb Blood Flow Capillary Leak Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • B. S. Abella
  • L. B. Becker

There are no affiliations available

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