Vasopressin and Hypothalamic-Pituitary-Adrenal Axis Relationships
The relationship between vasopressin and the hypothalamo-pituitary-adrenal (HPA) axis has been established for many years, one that occurs at almost every level of the HPA axis, as described in a recent review . Unfortunately, few clinical implications have been drawn from this finding, until now. Many fundamental studies have demonstrated the complexities of these physiological interactions. In an era of renewed interest for vasopressin and corticosteroid supportive therapies in sepsis [2, 3], the time has come for critical care specialists to gain better insight into how these two important hormonal systems interact together in physiological conditions. The present chapter is aimed at extrapolating this knowledge to septic settings and targeting specific queries and areas of future research.
KeywordsCorticotropin Release Factor ACTH Level Corticotropin Release Hormone ACTH Secretion Zona Glomerulosa
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