Induction of Ischemic Tolerance in the Brain: A Novel Neuroprotective Strategy?

  • A. M. Brambrink
  • I. P. Körner
Conference paper


Neurons are strongly dependent on continuous substrate delivery; accordingly physiologic resistance of neuronal tissues against ischemia is very low. Even short periods of cerebral ischemia can, therefore, cause severe neuronal damage. Certain surgical procedures (for example, during cardiovascular- or neuro-surgery) may involve periods of decreased or diminished cerebral perfusion, putting the patient at risk for neuronal damage and subsequent neurological deficit. Physicians caring for these patients will try to prevent or reduce damage using different neuroprotective strategies (aimed mainly at the reduction of cerebral metabolism). In addition to this, a modulation of neuronal ischemic tolerance (‘preconditioning’) prior to respective operative interventions may add substantially to the further improvement in patient outcome.


Cerebral Ischemia Ischemic Precondition Cereb Blood Flow Global Cerebral Ischemia Ischemic Tolerance 
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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • A. M. Brambrink
  • I. P. Körner

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