New Light on Volume Therapy in the Critically Ill?

  • J. Boldt
Conference paper


Hypovolemia is extremely common among intensive care unit (ICU) patients. Fluid deficits in the ICU patient can occur in the absence of obvious fluid loss secondary to vasodilation or generalized alterations of the endothelial barrier resulting in diffuse capillary leak. Patients with sepsis/septic shock, in particular, often show large fluid deficits. Sepsis is characterized by a pan-endothelial injury with subsequent development of increased endothelial permeability, loss of proteins, and interstitial edema [1, 2] leading to fluid shift from the intravascular to the interstitial compartment.


Intensive Care Unit Patient Hydroxyethyl Starch Major Abdominal Surgery Volume Replacement Volume Therapy 
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© Springer-Verlag Berlin Heidelberg 2003

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  • J. Boldt

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