Trials on Surfactant Replacement Therapy in Patients with ARDS

  • M. J. Schultz
  • J. Kesecioglu
  • B. Lachmann
Conference paper


Surfactant is synthesized by alveolar type II cells, stored in the lamellar bodies, and secreted to the alveolar space where it covers the epithelial surface [1]. Surfactant consists of phospholipids (85%), different proteins, lipids, and carbohydrates [2]. Surfactant proteins (SP)-B and SP-C are small, extremely hydrophobic proteins that are important in surfactant dynamics within the terminal air spaces and are an essential part in the reduction of surface tension [3]. The composition of surfactant changes in various disease states [4], which leads to alveolar instability, alveolar flooding and alveolar collapse. Initially, surfactant abnormalities were found in infant respiratory distress syndrome (IRDS); later on, changes in the surfactant system were also demonstrated in acute respiratory distress syndrome (ARDS) [5, 6]. Both qualitative and quantitative changes of surfactant have been described in patients with established ARDS [6–8], and in patients at risk for ARDS [8].


Acute Lung Injury Acute Respiratory Distress Syndrome Adult Respiratory Distress Syndrome Surfactant Protein Acute Respiratory Distress Syndrome Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • M. J. Schultz
  • J. Kesecioglu
  • B. Lachmann

There are no affiliations available

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