Trials on Surfactant Replacement Therapy in Patients with ARDS
Surfactant is synthesized by alveolar type II cells, stored in the lamellar bodies, and secreted to the alveolar space where it covers the epithelial surface . Surfactant consists of phospholipids (85%), different proteins, lipids, and carbohydrates . Surfactant proteins (SP)-B and SP-C are small, extremely hydrophobic proteins that are important in surfactant dynamics within the terminal air spaces and are an essential part in the reduction of surface tension . The composition of surfactant changes in various disease states , which leads to alveolar instability, alveolar flooding and alveolar collapse. Initially, surfactant abnormalities were found in infant respiratory distress syndrome (IRDS); later on, changes in the surfactant system were also demonstrated in acute respiratory distress syndrome (ARDS) [5, 6]. Both qualitative and quantitative changes of surfactant have been described in patients with established ARDS [6–8], and in patients at risk for ARDS .
KeywordsAcute Lung Injury Acute Respiratory Distress Syndrome Adult Respiratory Distress Syndrome Surfactant Protein Acute Respiratory Distress Syndrome Patient
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