Abstract
The dimorphic zoopathogenic fungus, Histoplasma capsulatum (Hc) is distributed worldwide and causes a broad spectrum of disease in man and other mammals. The vast majority of infections are acquired by inhalation of spores or fragments of the mycelial phase that is present in contaminated soil. After lodging within the pulmonary alveoli, spores or mycelial fragments convert to the yeast form of Hc that causes all subseqent disease manifestations. During the initial phase of infection, patches of pneumonitis are observed that contain a predominance of macrophages (MO) within which the Histoplasma yeasts appear to multiply with a generation time estimated to be 9–11 hours.1–4 Thus, during primary infection of the lung, pulmonary MO presumably bind and phagocytose Hc yeasts in the absence of significant opsonizing activity thereby providing a favorable intracellular environment for multiplication of the organisms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. A. Goodwin, J. E. Loyd, R. M. Des Prez. Histoplasmosis in normal hosts. Medicine. 60: 231 (1981).
J. J. Procknow, M. I. Page, C. G. Loosli. Early pathogenesis of experimental histoplasmosis. Arch. Pathol. 69:413 (1960).
R. P. Baughman, C. K. Kim, A. Vinegar, D. E. Hendricks, P. J. Schmidt, and W. E. Bullock. The pathogenesis of experimental pulmonary histoplasmosis: correlative studies of histopathology, bronchoalveolar lavage, and respiratory function. Amer. Rev. Resp. Dis. (in press).
D. H. Howard. Intracellular growth of Histoplasma capsulatum. J. Bacteriol. 89: 518 (1965).
W. E. Bullock, and S. D. Wright. The Role of the adherence-promoting receptors, CR3, LFA-1, and P150,95 in binding of Histoplasma capsulatum by human macrophages. J. Exp. Med. 165: 195 (1987).
S. D. Wright, and S. C. Silverstein. Tumor-promoting phorbol esters stimulate C3b and C3b’ receptor-mediated phagocytosis in cultured human monocytes. J. Exp. Med. 156: 1149 (1982).
S. D. Wright, and M. T. C. Jong. Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. J. Exp. Med 164: 1876–1888 (1986).
S. D. Wright, P. E. Rao, W. C. Van Voorhis, L. S. Craigmyle, K. Iida, M. A. Talle, E. F. Westberg, G. Goldstein, and S. C. Silverstein. Identification of the C3bi receptor of human monocytes and macrophages by using mononuclear antibodies. Proc. Natl. Acad. Sci. USA 80: 569 (1983).
G. Strassman, T. A. Springer, D. D. Somers, and D. 0. Adams. Mechanisms of tumor cell capture by activated macrophages: evidence for involvement of lymphocyte function-associated (LFA)-1 antigen. J. Immunol. 136: 4329 (1986)
J. M. Harlan, P. D. Killen, F. M. Senecal, B. R. Schwartz, E. K. Yee, F. R. Taylor, P. G. Beatty, T. H. Price, and H. D. Ochs. The role of neutrophil membrane glycoprotein GP-150 in neutrophil adhesion to endothelium in vitro. Blood 66: 167 (1985).
H. J. Muller-Eberhard, and R. D. Schreiber. Molecular biology and chemistry of the alternative pathway of complement. Adv. Immunol. 29: 1 (1980).
J.K. Czop, and K. F. Austen. A g-glucan inhibitable receptor of human monocytes: Its identity with the phagocytic receptor for particulate activators of the alternative complement pathway. J. Immunol. 134: 2588 (1985).
W. D. Ratnoff, J. M. Pepple, and J. A. Winkelstein. Activation of the alternate complement pathway by Histoplasma capsulatum. Infect. Immun. 30:147 (1980).
D. P. Speert, and S. C. Silverstein. Phagocytosis of unopsonized zymosan by human monocyte-derived macrophages: maturation and inhibition by mannan. J. Leukocyte Biol. 38: 655 (1985).
G. A. Warr. A macrophage receptor for (rnannose/glucosamine)glycoproteins of potential importance in phagocytic activity. Biochem. Biophys. Res. Commun. 93: 737 (1980).
M. E. Wilson, and R. D. Pearson. Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism. J. Immunol. 1386: 4681–4688 (1986).
T. Mokoena, and S. Gordon. Human macrophage activation, modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma dna alpha interferons, and dexamethasone. J. Clin. Invest. 73:624 (1985).
G. D. Ross, J. A. Cain, P. J. Lachmann. Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b. J. Immunol. 134: 3307 (1985).
K. Barr, R. A. Laine, and R. L. Lester. Carbohydrate structures of three novel phosphoinosital-containing sphingolipids from the yeast Histoplasma capsulatum. Biochemistry 23: 5589 (1984).
R. D. Diamond, R. Krzesicki, and W. Jao. Damage to Pseudohyphal forms of Candida albicans by neutrophils in the absence of serum in vitro. J. Clin. Invest. 61: 349 (1978).
R. D. Diamond, and R. Krzesicki. Mechanisms of attachment of neutrophils to Candida albicans Pseudohyphae in the absence of serum, and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro. J. Clin. Invest. 61: 360 (1978).
R. D. Diamond and C.C. Haudenschild. Monocyte-mediated serum-independent damage to hyphal and pseudohyphal forms of Candida albicans in vitro. J. Clin. Invest. 67: 173 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bullock, W.E., Wright, S.D. (1988). Recognition and Binding of Pathogenic Yeasts by Adhesion Molecules of Human Macrophages. In: Eisenstein, T.K., Bullock, W.E., Hanna, N. (eds) Host Defenses and Immunomodulation to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5421-6_5
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5421-6_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5423-0
Online ISBN: 978-1-4757-5421-6
eBook Packages: Springer Book Archive