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Host Defenses and Immunomodulation to Intracellular Pathogens pp 367–378Cite as

Induction of Immunosuppressive B-Lymphocytes with Components of Candida Albicans

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 239))

Abstract

Infections with Candida albicans are associated with a depressed immune response. The immunological profile present during candidiasis is extremely complex. Certain individuals with a congenital defect in the development of a normal cellular immune system are frequently the subject of clinical Candida disease involving mucocutaneous tissues (reviewed in 1). On the other hand, disseminated candidiasis is frequently encountered in individuals suffering with polymorphonuclear leukocyte function such as chronic granulomatous disease, myeloperoxidase deficiency, or Chediak-Higashi Syndrome (2,3,4). Individuals who manifest both mucocutaneous and disseminated forms of candidiasis are rare. The mode of resistance against these two forms of candidiasis presents a paradox since immune mechanisms effective in the first case apparently do not operate in the other.

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References

  1. Rogers, T. J., and E. Balish. 1980. Immunity to Candida albicans. Microbiol. Rev. 44: 660–682.

    CAS  Google Scholar 

  2. Lehrer, R. I. 1970. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal myeloperoxidase deficient, and chronic granulomatous disease neutrophils. Infect. Immun. 2: 42–47.

    Google Scholar 

  3. Lehrer, R. I. 1971. Measurement of candidacidal activity of specific leukocyte types in mixed cell poulations. H. Normal and chronic granulomatous disease eosinophils. Infect. Immun. 3: 800–802.

    Google Scholar 

  4. Anderson, W. D. 1971. Pathology. C. V. Mosby Co., St. Louis.

    Google Scholar 

  5. Valdimarsson, H., J. Higgs, R. Wells, M. Yamamura, J. Hobbs, and P. Holt. 1973. Immune abnormalities associated with chronic mucocutaneous candidiasis. Cell. Immunol. 11: 348–361.

    Google Scholar 

  6. Paterson, P., R. Semo, B. Blumenschein, and J. Swetlstad. 1971. Mucocutaneous anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy. Clin. Exp. Immunol. 9: 595–602.

    Google Scholar 

  7. Kirkpatrick, C., R. Rich, and J. Bennett. 1971. Chronic mucocutaneous candidiasis: model-building in cellular immmunity. Ann. Intern. Med. 74: 955–978.

    Google Scholar 

  8. Budtz-Jorgensen, E. 1973. Cellular immunity in acquired candidiasis of the palate. Scand. J. Dent. Res. 81: 372–382.

    Google Scholar 

  9. Fischer, G., and L. Horbach. 1958. Untersuchungen uber Promunitat und Infektionsimmunitat bei der experimentallen Soorinfektion. Arch. Hyg. Bakteriol. 142: 14–25.

    Google Scholar 

  10. Mankiewicz, E., E. Stackiewicz, and M. Liivak. 1959. A polysaccharide isolated f om Candida albicans as a growth promoting factor for tuberculosis. Can. J. Microbiol. 5: 261–267.

    Google Scholar 

  11. Mankiewicz, E., and M. Liivak. 1960. Effect of Candida albicans on the evolution of experimental tuberculosis. Nature (London) 187: 250251.

    Google Scholar 

  12. Ferrante, A., and T. H. Thong. 1980. The effect of amphotericin B treatment on Candida albicans-induced imunosuppression in mice. Immunol. Lett. 1: 321–323.

    Google Scholar 

  13. Vardinon, N., and E. Segal. 1979. Suppressive action of Candida albicans on the immune system in mice. Exp. Cell. Biol. 47: 275–280.

    Google Scholar 

  14. Rogers, T., and E. Balish. 1978. Suppression of lymphocyte blastogenesis by Candida albicans. Clin. Immunol. Immunopathol. 10: 298305.

    Google Scholar 

  15. Rivas, V. and T. Rogers. 1983. Studies on the nature of albicans-induced suppression. Candida J. Immunol. 130: 376–379.

    Google Scholar 

  16. Cuff, C., C. Rogers, B. Lamb, suppressor cells in vitro by and T. Rogers. 1986. Induction of Candida albicans. Cell. Immunol. 100: 47–56.

    Google Scholar 

  17. Bruce, J. F. Symington, T. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127: 2496–2501.

    CAS  PubMed  Google Scholar 

  18. Raychaudhuri, S., and M. Cancro. 1985. Cellular basis for neonatally induced T-suppressor activity. J. Exp. Med. 161: 816–829.

    Google Scholar 

  19. Smith, H., L. Jaffe, D. Kastner, and A. Steinberg. 1986. Evidence that Lyb-5 is a differentiation antigen in normal and xid mice. J. Immunol. 136: 1194–1200.

    CAS  PubMed  Google Scholar 

  20. Piccolella, E., G. Lombardi, and R. Morelli. 1981. Generation of suppressor cells in the response of human lymphocytes to a polysaccharide from Candida albicans. J. Immunol. 126: 2151–2155.

    CAS  PubMed  Google Scholar 

  21. Picolella, E., G. Lombardi, and R. Morelli. 1981. Mitogenic response of human peripheral blood lymphocytes to a purified C. albicans polysaccharide fraction: lack of helper activities is responsible for the in vitro unresponsiveness to a second antigenic challenge. J. Immunol. 126: 2156–2160.

    Google Scholar 

  22. Lombardi, G., D. Vismara, E. Picolella, V. Colizzi, and G. Asherson. 1985. Non-specific inhibitor produced by Candida albicans activated T-cells impairs cell proliferation by inhibiting interleukin-1 production. Clin. Exp. Immunol. 60: 303–310.

    Google Scholar 

  23. Mond, J., J. Farrar, W. Paul, J. Fuller-Farrar, M. Schaefer, and M. Howard. 1983. T-cell dependence and factor reconstitution of in vitro antibody responses to TNP-B. abortus and TNP-Ficoll: restoration of depleted responses with chromatographed fractions of a T-cell-derived factor. J. Immunol. 131: 633–637.

    CAS  PubMed  Google Scholar 

  24. Mathur, S., J. Melchers III, E. Ades, H. Williamson, and H. Fudenberg. 1980. Anti-ovarian and anti-lymphocyte antibodies in patients with chronic vaginal candidiasis. J. Reprod. Immunol. 2: 247–262.

    Google Scholar 

  25. Fischer, A., J. Ballet, and C. Griscelli. 1978. Specific inhibition of in vitro Candida-induced lymphocyte proliferation by polysaccharide antigens present in the serum of patients with chronic mucocutaneous candidiasis. J. Clin. Invest. 62: 1005–1013.

    Google Scholar 

  26. Fischer, A., L. Pichat, M. Audinot, and C. Griscelli. 1982. Defective handling of mannan by monocytes in patients with chronic mucocutaneous candidiasis resulting in a specific cellular unresponsiveness. Clin. Exp. Immunol. 47: 653–660.

    Google Scholar 

  27. Piccolella, E., G. Lombardi, and R. Morelli. 1980. Human lymphocyte activating properties of a purified polysaccharide from Candida albicans: B and T cell cooperation in the mitogenic response. J. Immunol. 125: 2082–2088.

    CAS  PubMed  Google Scholar 

  28. Carrow, E., and J. Domer. 1985. Immunoregulation in experimental murine candidiasis:specific suppression induced by Candida albicans cell wall glycoprotein. Infect. Immun. 49: 172–181.

    Google Scholar 

  29. Cassone, A., P. Marconi, F. Bistoni, E. Mattia, G. Sbaraglia, E. Garaci, and E. Bonmassar. 1981. Immunoadjuvant effects of Candida albicans and its cell wall fractions in a mouse lymphoma model. Clin. Immunol. Immunother. 10: 181–190.

    Google Scholar 

  30. Smail, E. and J. Jones. 1984. Demonstration and solubilization of antigens expressed primarily on the surfaces of Candida albicans germ tubes. Infect. Immun. 45: 74–81.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Christopher F. Cuff, Beryl Packer, Victor Rivas, Christina M. Rogers, Antonio Cassone, Raymond Donnelly, Raymond Donnelly & Thomas J. Rogers

  2. Instituto Superiore di Sanita, Laboratory of Bacteriology and Medical Mycology, Rome, Italy

    Christopher F. Cuff, Beryl Packer, Victor Rivas, Christina M. Rogers, Antonio Cassone & Thomas J. Rogers

Authors
  1. Christopher F. Cuff
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  2. Beryl Packer
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  3. Victor Rivas
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  4. Christina M. Rogers
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  5. Antonio Cassone
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  6. Raymond Donnelly
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  7. Thomas J. Rogers
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein Ph.D. (Professor of Microbiology and Immunology) (Professor of Microbiology and Immunology)

  2. Division of Infectious Diseases, University of Cincinnati Medical Center, Cincinnati, Ohio, USA

    Ward E. Bullock M.D. (Head) (Head)

  3. Department of Immunology and Anti-infectives Therapy, Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    Nabil Hanna Ph.D. (Director) (Director)

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© 1988 Springer Science+Business Media New York

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Cuff, C.F. et al. (1988). Induction of Immunosuppressive B-Lymphocytes with Components of Candida Albicans . In: Eisenstein, T.K., Bullock, W.E., Hanna, N. (eds) Host Defenses and Immunomodulation to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5421-6_35

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  • DOI: https://doi.org/10.1007/978-1-4757-5421-6_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5423-0

  • Online ISBN: 978-1-4757-5421-6

  • eBook Packages: Springer Book Archive

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