Induction of Immunosuppressive B-Lymphocytes with Components of Candida Albicans

  • Christopher F. Cuff
  • Beryl Packer
  • Victor Rivas
  • Christina M. Rogers
  • Antonio Cassone
  • Raymond Donnelly
  • Thomas J. Rogers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Infections with Candida albicans are associated with a depressed immune response. The immunological profile present during candidiasis is extremely complex. Certain individuals with a congenital defect in the development of a normal cellular immune system are frequently the subject of clinical Candida disease involving mucocutaneous tissues (reviewed in 1). On the other hand, disseminated candidiasis is frequently encountered in individuals suffering with polymorphonuclear leukocyte function such as chronic granulomatous disease, myeloperoxidase deficiency, or Chediak-Higashi Syndrome (2,3,4). Individuals who manifest both mucocutaneous and disseminated forms of candidiasis are rare. The mode of resistance against these two forms of candidiasis presents a paradox since immune mechanisms effective in the first case apparently do not operate in the other.


Candida Albicans Chronic Granulomatous Disease Suppressor Cell Chronic Mucocutaneous Candidiasis Chronic Mucocutaneous Candidiasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Christopher F. Cuff
    • 1
    • 2
  • Beryl Packer
    • 1
    • 2
  • Victor Rivas
    • 1
    • 2
  • Christina M. Rogers
    • 1
    • 2
  • Antonio Cassone
    • 1
    • 2
  • Raymond Donnelly
    • 1
    • 1
  • Thomas J. Rogers
    • 1
    • 2
  1. 1.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA
  2. 2.Instituto Superiore di SanitaLaboratory of Bacteriology and Medical MycologyRomeItaly

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