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Decreased Mitogenic Response of Murine Spleen Cells Following Intraperitoneal Injection of Serovar-Specific Glycopeptidolipid Antigens from the Mycobacterium Avium Complex

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Host Defenses and Immunomodulation to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 239))

Abstract

Mycobacteria in the Mycobacterium avium complex have recently become clinically important opportunistic pathogens with a demonstrated ability to cause severe disseminated infections in patients suffering from AIDS (6,7,9,13). Although there are a variety of other nontuberculous mycobacteria that can infect humans, it appears that only certain serovars of the MAC are the most common to be associated with individuals who have AIDS (14). It has been suggested that the increased number of MAC infections in AIDS patients may be due to an immunologic defect which selectively favors these mycobacteria over other nontuberculous mycobacteria (14).

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References

  1. Barrow, W. W., Ullom, B. P., and Brennan, P. J. 1980. Peptidoglycolipid nature of the superficial cell wall sheath of smoothcolony-forming mycobacteria. J. Bacteriol. 144: 814–822.

    CAS  PubMed Central  PubMed  Google Scholar 

  2. Barrow, W. W., and Brennan, P. J. 1982. Immunogenicity of type-specific C-mycoside glycopeptidolipids of mycobacteria. Infect. Immun. 36: 678–684.

    Google Scholar 

  3. Brennan, P. J., and Goren, M. B. 1979. Structural studies on the type-specific antigens and lipids of the Mycobacterium aviumMycobacterium intracellulare-Mycobacterium scrofulaceum serocomplex. J. Biol. Chem. 254: 4205–4211.

    Google Scholar 

  4. Brennan, P. J., Souhrada, M., Ullom, B., McClatchy, J. K., and Goren, M. B. 1978. Identification of atypical mycobacteria by thin-layer chromatography of their surface antigens. J. Clin. Microbiol. 8: 374–379.

    Google Scholar 

  5. Collins, F. M. 1986. Mycobacterium aviumcomplex infections and development of the Acquired Immunodeficiency Syndrome: Casual opportunist or causal co-factor? Int. J. Lepr. 54: 458–474.

    Google Scholar 

  6. Fainstein, V., Bolivar, R., Mavligit, G., Rios, A., Luna, M. 1982. Disseminated infection due to Mycobacterium avium-intracellulare in a homosexual man with Kaposi’s sarcoma. J. Infect. Dis. 145: 586.

    Google Scholar 

  7. Greene, J. B., Sidhu, G. S., Lewin, S., Levine, J., Masur, H., Simberkiff, M. S., Nicholas, P., Good, R. C., Zolla-Pazner, S. B., Pollock, A. A., Tapper, M. L. and Holzman, R. S. 1982. Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers, Ann. Intern. Med. 97: 539–546.

    Google Scholar 

  8. Hooper, L. C., Johnson, M. M., Khera, V. R., and Barrow, W. W. 1986. Macrophage uptake and retention of radiolabeled glycopeptidolipid antigens associated with the L1 layer of Mycobacterium intracellulare serovar 20. Infect. Immun. 54: 133–141.

    Google Scholar 

  9. Kiehn, T. E., Edwards, F. F., Brannon, P., Tsang, A. Y., Maio, M., Gold, J. W. M., Whimbey, E., Wong, B., McClatchy, J. K. and Armstrong, D. 1985. Infections caused by Mycobacterium avium complex in immunocompromised patients: Diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics. J. Clin. Microbiol. 21: 168–173.

    Google Scholar 

  10. Li, C. Y., Lam, K. W., and Yam, L. T. 1973. Esterases in human leukocytes. J. Histochem. Cytochem. 21: 1–12.

    Google Scholar 

  11. Lowery, 0., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with folin phenol reagent. J. Biol. Chem., 193: 265–275.

    Google Scholar 

  12. Luster, M. I., Dean, J. H., and Moore, J. A. 1982. Evaluation of immune functions in toxicology, In: “Principles and Methods of Toxicology,” Hayes, A. W., ed., New York, pp. 561–586.

    Google Scholar 

  13. Macher, A. M., Kovacs, J. A., Gill, V., Roberts, G. D., Ames, J., Park, C. H., Straus, S., Lane, H. C., Pararillo, J. E., Fauci, A. S. and Masur, H. 1983. Bacteremia due to Mycobacterium avium-intracellulare in the acquired immunodeficiency syndrome. Ann. Intern. Med. 99: 782–785.

    Google Scholar 

  14. Masur, H. 1982. Mycobacterium avium-intracellulare: Another scourge for individuals with the Acquired Immunodeficiency Syndrome. J.A.M.A. 248: 3013.

    Google Scholar 

  15. Schaefer, W. B. 1965. Serologic identification and classification of the atypical mycobacteria by their agglutination. Am. Rev. Respir. Dis. 92: 85–93.

    Google Scholar 

  16. Tereletsky, M. J., and Barrow, W. W. 1983. Postphagocytic detection of glycopeptidolipids associated with the superficial L1 layer of Mycobacterium intracellulare Infect. Immun. 41: 1312–1321.

    CAS  Google Scholar 

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© 1988 Springer Science+Business Media New York

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Hooper, L.C., Barrow, W.W. (1988). Decreased Mitogenic Response of Murine Spleen Cells Following Intraperitoneal Injection of Serovar-Specific Glycopeptidolipid Antigens from the Mycobacterium Avium Complex. In: Eisenstein, T.K., Bullock, W.E., Hanna, N. (eds) Host Defenses and Immunomodulation to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5421-6_31

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  • DOI: https://doi.org/10.1007/978-1-4757-5421-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5423-0

  • Online ISBN: 978-1-4757-5421-6

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