Immunoregulation in Human Tuberculosis
Infection of humans with Mycobacterium tuberculosis provides an attractive model for investigating regulation of the immune response for several reasons. First, the causative agent is cultivable on synthetic medium and a cDNA genomic expression library has been prepared. Therefore, purified native and recombinant mycobacterial antigens can be tested directly for immunoregulatory activity. Second, the immune response in healthy subjects with delayed-type hypersensitivity (DTH) to mycobacteria can be contrasted to patients with tuberculosis to elucidate patterns of immunoregulation which are characteristic of disease. Third, although infection with M. tuberculosis or attenuated mycobacteria is an excellent model for DTH in experimental systems, the paradoxic occurrence of anergy in some patients can be explored in the laboratory.
KeywordsPeripheral Blood Mononuclear Cell Large Granular Lymphocyte Mycobacterial Antigen Human Tuberculosis Suppressor Cell Activity
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