Partial Characterization of Suppressor Factors in Spleen Cell Culture Supernatants of Mycobacterium Lepraemurium-Infected Mice

  • L. Richard
  • A. Forget
  • R. Turcotte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


The presence of suppressor cells (macrophage-like and T lymphocytes) have been demonstrated in the spleen of mice infected with Mycobacterium lepraemurium (M.lm) (1, 2). These suppressor cells depressed several in vitro immune functions, such as the lymphoblastic responses to polyclonal mitogens to alloantigens (4) and to specific antigens (5), the generation of cytotoxic T-cell response and the expression of natural killing activity (Lemieux et al., unpublished results). Recently, we have found that splenic T-cell subpopulations from M.lminfected mice, when adoptively transferred to syngeneic mice, can depress the induction and/or the expression of the delayed-type hypersensitivity (DTH) to M.lm antigens (6).


Culture Supernatant Spleen Cell Suppressor Cell Cutaneous Leishmaniasis Syngeneic Mouse 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • L. Richard
    • 1
  • A. Forget
    • 2
  • R. Turcotte
    • 1
  1. 1.Institut Armand-FrappierUniversité du QuébecCanada
  2. 2.Faculté de MédecineUniversité de MontréalCanada

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