Effect of Tumor Necrosis Factor on Growth of Trypanosoma Musculi in Vivo and in Vitro

  • Patricia A. L. Kongshavn
  • Esfandiar Ghadirian
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Trypanosome musculi, a natural parasite of mice, produces a self-limiting infection which lasts for approximately 3 weeks and comprises an early growth phase, a plateau phase and an elimination phase (1). The mechanism of protection which controls the early growth of the parasite, leading to the plateau phase, is not well understood but is known to be highly sensitive to ionizing radiation. Macrophages of the reticuloendothelial system also become activated at this time (2). We have shown recently that elimination of parasitaemia and termination of the infection depends on an effector mechanism involving a thermolabile, anti-trypanosomal IgG2a antibody, complement component C3 and an effector cell, possibly a macrophage (3,4).


Plateau Phase Trypanosoma Cruzi Malarial Parasite Peritoneal Exudate Cell Natural Parasite 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Patricia A. L. Kongshavn
    • 1
  • Esfandiar Ghadirian
    • 1
  1. 1.Departments of Physiology and Medicine and Montreal General Hospital Research InstituteMcGill UniversityMontrealCanada

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