In Vivo and in Vitro Role of Gamma Interferon in Immune Clearance of Rickettsia species

  • Thomas R. Jerrells
  • Han Li
  • David H. Walker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Members of the genus Rickettsia are obligate intracellular bacteria, and due to the intracellular location of their growth, they present a unique challenge to the immune system. Since antibody cannot gain entrance to viable cells, it has been argued that antibody does not play a major role in the effector phase of immunity to these organisms.


L3T4 Cell Scrub Typhus Spotted Fever Rickettsial Infection Rickettsia Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Shirai, A., P.J. Catanzaro, S.M. Phillips, and J.V. Osterman. 1976. Host defenses in experimental scrub typhus: role of cellular immunity in heterologous protection. Infect. Immun. 14: 39.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Walker, D.J., and F.W. Henderson. 1978. Effect of immunosuppression on Rickettsia rickettsii infection in guinea pigs. Infect. Immun. 20: 221.PubMedCentralPubMedGoogle Scholar
  3. 3.
    Kokorin, I.N., E.A. Kabanova, E.M. Shirokova, G.E. Abrosimova, N.N. Rybkina, and V.I. Pushkareva. 1982. Role of T lymphocytes in Rickettsia conorii infection. Acta Virol. 26: 91.PubMedGoogle Scholar
  4. 4.
    Jerrells, T.R., and C.S. Eisemann. 1983. Role of T-lymphocytes in production to antigens of Rickettsia tsutsugamushi and other Rickettsia species. Infect Immun. 41: 666.Google Scholar
  5. 5.
    Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348.Google Scholar
  6. 6.
    Palmer, B.A., F.M. Hetrick, and T.R. Jerrells. 1984. Production of gamma interferon in mice immune to Rickettsia tsutsugamushi. Infect Immun. 43: 59.Google Scholar
  7. 7.
    Palmer, B.A., F.M. Hetrick, and T.R. Jerrells, 1984. Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi. Infect Immun. 46: 237.Google Scholar
  8. 8.
    MacMillan, J.G., R.M. Rice, and T.R. Jerrells. 1985. Development of antigen specific cell-mediated immune responses after infection of cynomolgus monkeys (Macaca fasicularis) with Rickettsia tsutsugamushi. J. Infect. Dis. 152: 739.Google Scholar
  9. 9.
    Unanue, E.R. 1984. Antigen-presenting function of the macrophage. Ann. Rev. Immunol. 2: 395.Google Scholar
  10. 10.
    Steeg, P.S., R.N. Moore, H.M. Johnson, and J.J. Oppenheim. 1982. Regulation of murine macrophage la antigen expression by a lymphokine with immune interferon activity. J. Exp. Med. 156: 1780.Google Scholar
  11. 11.
    Jerrells, T.R., J. Turco, H.H. Winkler, and G.L. Spitalney. 1986. Neutralization of lymphokine-mediated antirickettsial activity of fibroblasts and macrophages with monoclonal antibody specific for murine interferon gamma. Infect. Immun. 51: 355.Google Scholar
  12. 12.
    Turco, J., and H.H. Winkler. 1983. Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines. J. Exp. Med. 157: 974.Google Scholar
  13. 13.
    Wisseman, C.L., Jr., and A. Waddell. 1983. Interferon-like factors from antigen-and mitogen-stimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii infected human endothelial cells, fibroblasts, and macrophages. J. Exp. Med. 157: 1780.PubMedCrossRefGoogle Scholar
  14. 14.
    Jerrells, T.R., and C.J. Hickman. 1986. Down regulation of la antigen expression on inflammatory macrophages by factors produced during acute infections with R. tsutsugamushi in, Immune Regulation by Characterized Polypeptides, UCLA Symposia on Molecular and Cellular Biology Goldstein, G., J.F. Bach, and H. Wigzell, eds., New York, Alan R. Liss, Inc., vol. 41.Google Scholar
  15. 15.
    Spitalney, G.R., and E.A. Havell. 1984. Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. J. Exp. Med. 159: 1560.CrossRefGoogle Scholar
  16. 16.
    Walker, D.H., and F.W. Henderson. 1978. Effect of immunosuppression on Rickettsia rickettsii infection in guinea pigs. Infect. Immun. 20: 221.PubMedCentralPubMedGoogle Scholar
  17. 17.
    Jerrells, T.R. 1983. Association of inflammatory I region-associated antigen positive macrophage influx and genetic resistance of inbred mice to Rickettsia tsutsugamushi. Infect. Immun. 42: 549.Google Scholar
  18. 18.
    Eisemann, C.S., M.J. Nypaver, and J.V. Osterman. 1984. Susceptibility of inbred mice to rickettsiae of the spotted fever group. Infect. Immun. 43: 143.Google Scholar
  19. 19.
    Meltzer, M.S., and C.A. Nacy. 1980. Macrophages in resistance to rickettsial infection: susceptibility to the lethal effects of Rickettsia akari infection in mouse strains with defective macrophage function. Cell. Immunol. 54: 487.PubMedCrossRefGoogle Scholar
  20. 20.
    Nacy, C.A., and M.S. Meltzer. 1982. Macrophages in resistance to rickettsial infection: strains of mice susceptible to the lethal effects of Rickettsia akari show defective macrophage rickettsiacidal activity in vitro. Infect. Immun. 36: 1096.Google Scholar
  21. 21.
    Jerrells, T.R., and J.V. Osterman. 1982. Role of macrophages in innate and acquired host resistance to experimental scrub typhus infection of inbred mice. Infect. Immun. 37: 1066.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Thomas R. Jerrells
    • 1
  • Han Li
    • 1
  • David H. Walker
    • 1
  1. 1.Department of Pathology Route F-09University of Texas Medical BranchGalvestonUSA

Personalised recommendations