Validation of a Role for Endogenously Produced IFNγ in Resolution of Listeria Monocytogenes Infection in Mice

  • Robert D. Schreiber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


It is now well recognized that activated macrophages can express enhanced levels of cytocidal activity toward a variety of microbial targets and neoplastic cells (1–6). Three to five years ago, work from several laboratories indicated that IFNγ was one of the major classes of lymphokines capable of activating macrophages under well-defined in vitro conditions (7–14). Recently, there has been an explosive growth of experiments directed at defining IFNγ’s mechanism of action at the molecular level. These investigations have led to the identification and characterization of a specific IFNγ receptor on the macrophage plasma membrane (15–17), have provided insights into the mechanism of transmembrane signal transduction, (18–20), and have elucidated the ultimate fate of receptor bound ligand (16,21).


Peritoneal Macrophage Infected Mouse Peritoneal Cell Tumoricidal Activity Murine Peritoneal Macrophage 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Robert D. Schreiber
    • 1
  1. 1.Department of PathologyWashington Univ. School of MedicineSt. LouisUSA

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