Role of Natural Killer Cells in the Early Clearance of Rickettsia Typhi in Mice

  • F. M. Rollwagen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Clearance of the intracellular bacterium, Rickettsia typhi has been a field of much recent inquiry. Cells which transfer immunity arise late during the course of infection, bear the Thy-1 antigen (1) and are H-2 restricted. Further, H-2 restricted cytotoxic T-cells functional in vitro also arise at approximately the same time (2), and are believed to belong to the same lineage as those which transfer immunity (3). Examination of the kinetics of the immune response, however, reveals that the onset of the cellular response, as well as that of IgG antibodies, occurs as much as one week after the organisms have been cleared. How, then, is the early clearance of infection brought about?


Natural Killer Natural Killer Cell Visceral Leishmaniasis Natural Cytotoxic Rickettsial Infection 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • F. M. Rollwagen
    • 1
  1. 1.Infectious Disease DepartmentNaval Medical Research InstituteBethesdaUSA

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