Which T Cells are Relevant to Resistance Against Listeria Monocytogenes Infection?

  • Stefan H. E. Kaufmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Listeria monocytogenes is an intracellular bacterial pathogen for many mammals including man. Although endemic outbreaks of listeriosis have been reported it appears that the incidence of this disease is greatly underrated. While our knowledge about the epidemiology of listeriosis is still limited, a great deal of information has been gathered about the immune response against this pathogen. This is mostly due to the pioneering work of Mackaness, North and other investigators who have introduced L.monocytogenes to experimental immunology (summarized in 1). In these studies it has been shown that protective immunity depends on the interaction between specific T lymphocytes and mononuclear phagocytes (1–3). With the realization that the peripheral T-cell system consists of at least two well defined populations (summarized in 4) the question arose which of these T cell sets is relevant for the acquisition of resistance and which mechanisms are utilized.


Kupffer Cell Infected Mouse Listeria Monocytogenes Immune Mouse Cytolytic Activity 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Stefan H. E. Kaufmann
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of Ulm79, UlmFederal Republic of Germany

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