Cutaneous Leishmaniasis: Relative Role of T Cell Subsets

  • Richard Titus
  • Martine Marchand
  • Genevieve Milon
  • Gilles Marchal
  • Thierry Boon
  • Jacques Louis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)

Abstract

Leishmanias are protozoan parasites which are transmitted to their mammalian host by the bite of a sandfly vector (1). Upon entering the host, the flagellated promastigote form of the parasite which is injected by the sandfly is phagocytized by mononuclear phagocytic cells in which it transforms into the aflagellate amastigote form. Following infection of man by Leishmania several different forms of disease can ensue which depend upon the species of Leishmania carried by the sandfly. For example, a cutaneous form of leishmaniasis can be caused by L. major, L. mexicana or L. braziliensis a mucocutaneous form by L. braziliensis and a visceral form by L. donovani In addition, a spectrum of clinical manifestations can be observed in patients suffering from each of these forms of the disease which suggests that the pathologic changes observed in leishmaniasis are due to both the species of the infecting parasite and to the host response to the parasite.

Keywords

Cutaneous Leishmaniasis Surface Phenotype Lesion Progression Cell Deficient Mouse Major Histocompatibility Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Richard Titus
    • 1
    • 2
    • 3
    • 4
  • Martine Marchand
    • 1
    • 2
    • 3
    • 4
  • Genevieve Milon
    • 1
    • 2
    • 3
    • 4
  • Gilles Marchal
    • 1
    • 2
    • 3
    • 4
  • Thierry Boon
    • 1
    • 2
    • 3
    • 4
  • Jacques Louis
    • 1
    • 2
    • 3
    • 4
  1. 1.Harvard Medical SchoolBostonUSA
  2. 2.International Institute of Cellular and Molecular PathologyBrusselsBelgium
  3. 3.Unite d’Immunophysiologie CellulaireInstitut PasteurParisFrance
  4. 4.World Health Organization, Immunology Research and Training CenterInstitute of BiochemistryEpalingesSwitzerland

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