Changes in Size and Cell Populations in Lymphoid Organs during Plasmodium Chabaudi Infection in Resistant and Susceptible Mice
The level of host resistance to Plasmodium chabaudi is genetically determined by a major, dominant, autosomal, non H-2 linked gene which has been designated Pchr (for resistance to P. chabaudi) The genetic control was defined by our laboratory by analysis of hybrid and backcross progeny derived from the strain combination of resistant C57BL/6J (B) and susceptible A/J (A) mice and was confirmed by analysis of the AXB/BXA series of recombinant inbred (RI) strains (1,2). The RI strain analysis showed, furthermore, that resistance and, consequently, survival are genetically linked with marked splenomegaly while susceptibility and death are linked with minimal splenomegaly.
KeywordsPost Infection Recombinant Inbred Spleen Weight Susceptible Mouse Thymic Atrophy
Unable to display preview. Download preview PDF.
- 1.Stevenson, M.M., J.J. Lyanga and E. Skamene. 1982. Murine malaria: genetic control of resistance to Plasmodium chabaudi Infect. Immun. 38: 80–88.Google Scholar
- 2.Stevenson, M.M. and E. Skamene. 1985. Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi Infect. Immun. 47: 452–456.Google Scholar
- 4.Grun, J.L., C.A. Long and W.P. Weidanz. 1985. Effects of splenectomy on antibody-independent immunity to Plasmodium chabaudi adami malaria. Infect. Immun. 48: 853–858.Google Scholar
- 5.Roberts, D.W. and W.P. Weidanz. 1978. Splenomegaly, enhanced phagocytosis and anemia are thymus dependent responses to malaria. Infect. Immun. 20: 728–731.Google Scholar
- 6.Cavacini, L.A., C.A. Long and W.P. Weidanz. 1986. T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells. Infect. Immun. 52: 637–643.Google Scholar
- 8.Taliaferro, W.H. and H.W. Mulligan. 1937. The histopathology of malaria with special reference to the function and origin of the macrophages in defence. Indian Med. Res. Mem. 29: 1–138.Google Scholar
- 9.Moran, C., V. DeRivera and J. Turk. 1973. The immunological significance of histological changes in the spleen and liver in mouse malaria. Clin. Exp. Immunol. 13: 467–478.Google Scholar
- 10.Weiss, L., U. Geduldid and W. Weidanz. 1986. Mechanisms of splenic control of murine malaria: reticular cell activation and the development of a blood-spleen barrier. Am. J. Anat. 176: 251–285.Google Scholar
- 11.Krettli, A.U. and R. Nussenzweig. 1974. Depletion of T and B lymphocytes during malarial infection. Cell. Immunol. 13: 440–446.Google Scholar
- 12.Gravely, S.M., J. Hamburger and J.P. Kreier. 1976. T and B cell population changes in young and in adult rats infected with Plasmodium berghei Infect. Immun. 14: 178–183.Google Scholar
- 13.Stevenson, M.M. and E. Skamene. 1986. Modulation of Primary Antibody Responses to Sheep Erythrocytes in Plasmodium chabaudi-infected resistant and susceptible mouse strains. Infect. Immun. 54: 600–602.Google Scholar