Interaction of Legionella Pneumophila with Peritoneal Macrophages from Various Mouse Strains

  • Yoshimasa Yamamoto
  • Thomas W. Klein
  • Catherine A. Newton
  • Herman Friedman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


Legionella pneumophila (Lp) is a facultative intracellular bacterium which causes legionellosis in humans. This bacterium replicates well in cultures of human and guinea pig mononuclear phagocytes (1,2), and infections caused by these organisms appear to correlate with the host’s cellular immune system (3). In this regard, the importance of mononuclear phagocytes in legionellosis has been suggested by a number of investigators (4,5,6). Guinea pigs are susceptible to infection with Lp and have been widely used as an animal model for legionellosis (7). Although the mouse has been found highly useful for studying infection and immunity to a variety of bacteria, this animal species appears to be relatively resistant to Lp infection (7). Moreover, it has been reported that Lp is markedly restricted in peritoneal macrophages obtained from most inbred mouse strains, even at relatively high infectivity ratios (8). Recently, we observed that macrophages from the A/J inbred mouse strain supported the intracellular growth of Lp. In the present study, we report on the permissive nature of A/J macrophages for Lp growth and the possible involvement of permissive cells in host resistance to infection.


Colony Form Unit Peritoneal Macrophage Peritoneal Lavage Viable Bacterium Inbred Mouse Strain 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Yoshimasa Yamamoto
    • 1
  • Thomas W. Klein
    • 1
  • Catherine A. Newton
    • 1
  • Herman Friedman
    • 1
  1. 1.University of South Florida, College of MedicineTampaUSA

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