Abstract
Gangliosides are sialic acid-containing glycosphingolipids found in the plasma membrane of virtually all vertebrate tissues and are particularly abundant in the nervous system (Ledeen and Yu, 1982; Ledeen, 1983; Ando, 1983; Ledeen, 1985). Gangliosides comprise a major part of the glycoconjugate network extending from the neuronal membrane surface. Recent investigations suggest that gangliosides may exert a critical role in the regulation of cell growth and differentiation (Hakomori, 1981; 1983; Ledeen et al., 1984; Ando, 1983; Ledeen, 1984). Nevertheless, the molecular events which underlie the physiological and cellular events remain unresolved. Recent investigations have emphasized the importance of Ca++-dependent kinase systems in the regulation of many dynamic cellular processes (Nestler et al., 1984; Cheung, 1982; DeLorenzo and Goldenring, 1984). In particular, the Ca+ +/calmodulin-dependent kinase (Kennedy, 1983) and the Ca+ + /phospholipid-dependent kinase (C-kinase) system (Nishizuka, 1984a,b) have been implicated as major regulators of cellular physiology. Gangliosides bind Ca+ + with high affinity (Abramson et al., 1972; Probst et al., 1979; 1984; Quarles and Folch-Pi, 1965; Rahmann, 1983), and thus, their possible interaction with Ca+ + -dependent kinases is of great interest. We present here our recent investigations which indicate that gangliosides may exert opposite effects on these Ca+ +-dependent kinases with inhibition of C-kinase and stimulation of calmodulin-dependent kinase (Goldenring et al., 1985; Kim et al., 1986).
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Abbreviations
- EGTA:
-
ethylene -bis(oxyethylenenitrile) tetraacetic acid
- MBP:
-
myelin basic protein
- CaM:
-
calmodulin
- IC50 :
-
concentration for 50% inhibition
- SDS:
-
sodium dodecylsulphate
- PAGE:
-
polyacrylamide gel electrophoresis.
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© 1986 Springer-Verlag Berlin Heidelberg
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Yu, R.K., Goldenring, J.R., Kim, J.Y.H., DeLorenzo, R.J. (1986). Gangliosides as Differential Modulators of Membrane-Bound Protein Kinase Systems. In: Tettamanti, G., Ledeen, R.W., Sandhoff, K., Nagai, Y., Toffano, G. (eds) Gangliosides and Neuronal Plasticity. FIDIA Research Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5309-7_8
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DOI: https://doi.org/10.1007/978-1-4757-5309-7_8
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