Expression of Ganglioside-Antigens During Neuronal Differentiation Studied by Use of Monoclonal Antibodies
Progress in development and maturation of the brain has been shown to be paralleled by changes of gangliosides (Rösner, 1982). One generalization of these studies was that predominance of GD3 may characterize mitotically active precursor cells (Dreyfus et al., 1975; Rösner, 1980; 1982; Rösner et al., 1985; Goldmann et al., 1984) and accretion of more complex gangliosides indicates the transition to postmitotic young neurons (Rösner, 1980; 1982). In the present study, performed with chicken and rat embryos, immunohistochemical data obtained with monoclonal antibodies to gangliosides support the above conclusion.
KeywordsDorsal Root Ganglion Retinal Ganglion Cell Ventricular Zone Cortical Plate Postmitotic Neuron
sodium phosphate buffer
biotirylated antimousa IgG
fluoresciein-labeled antimouse IgG
dorsal root ganglion
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