Expression of Ganglioside-Antigens During Neuronal Differentiation Studied by Use of Monoclonal Antibodies

  • H. Rösner
  • C. J. Willibald
  • S. Henke-Fahle
Part of the FIDIA Research Series book series (FIDIA, volume 6)


Progress in development and maturation of the brain has been shown to be paralleled by changes of gangliosides (Rösner, 1982). One generalization of these studies was that predominance of GD3 may characterize mitotically active precursor cells (Dreyfus et al., 1975; Rösner, 1980; 1982; Rösner et al., 1985; Goldmann et al., 1984) and accretion of more complex gangliosides indicates the transition to postmitotic young neurons (Rösner, 1980; 1982). In the present study, performed with chicken and rat embryos, immunohistochemical data obtained with monoclonal antibodies to gangliosides support the above conclusion.


Dorsal Root Ganglion Retinal Ganglion Cell Ventricular Zone Cortical Plate Postmitotic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



thin chromatography


sodium phosphate buffer


biotirylated antimousa IgG


fluoresciein-labeled antimouse IgG


fluoresciein-labeled avidin


polysialoganglioside-associated antigen


dorsal root ganglion


ventral root




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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Rösner
    • 1
  • C. J. Willibald
    • 1
  • S. Henke-Fahle
    • 2
  1. 1.Institute of ZoologyUniversity of Stuttgart-HohenheimStuttgart 70Germany
  2. 2.Max-Planck-Institute for Developmental Biology7400 TübingenFederal Republic of Germany

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