Skip to main content
SpringerLink
Log in

Topographical Distribution of the Gangliosides in the Developing and Adult Human Brain

  • Chapter
Gangliosides and Neuronal Plasticity

Part of the book series: FIDIA Research Series ((FIDIA,volume 6))

Abstract

In contrast to the experimental knowledge about gangliosides, there are relatively few studies describing gangliosides in the developing (Vanier et al., 1971; Yusuf et al., 1977; Martinez and Ballabriga, 1978; Kracun et al., 1983) and adult (Suzuki, 1965; Riboni et al., 1985) human brain. The developmental studies revealed that the prenatal period of “growth spurt”, occurring between 15 and 30 weeks of gestation (Sidman and Rakic, 1973), is paralleled by an increase in the content of gangliosides and a change in their composition. In animal studies similar developmental changes of gangliosides have been confirmed as consecutive phenomena of neuron genesis, neuronal differentiation, synaptogenesis and myelination (Dreyfus et al., 1980; Rösner, 1977; 1980; 1982).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

A:

amygdalea

As:

area subcallosa

Cc:

cerebellar cortex

CC:

corpus callosum

CI:

capsula interna

CIn:

colliculi inferiores

CM:

corpora mammillaria

CS:

colliculi superiores

E:

epiphysis (pineal gland)

F:

frontal cortex

FW:

frontal white matter

gC:

gyrus cinguli

Gd:

gyrus dentatus

GP:

globus pallidus

h:

hippocampus

Hy:

hypothalamus

I:

insular cortex

LC:

locus coeruleus

Nac:

nucleus accumbens

NBM:

nucleus basalis Meynert

NC:

nucleus caudatus

NeuAc:

N-acetylneuraminic acid

Nr:

nucleus ruber

Oc:

occipital cortex

Of:

orbitofrontal cortex

oh:

optic chiasma

P:

putamen

Pf:

prefrontal cortex

Pr:

parietal cortex

Sn:

substantia nigra

Sr:

striatal (visual) cortex

T:

temporal cortex

TLC:

thin-layer chromatography

Th:

thalamus

Thp:

pulvinar thalami

To:

paleocortex (tuberculum olfactorium).

References

  • Dreyfus H, Louis JC, Harth S, Mandel P (1980) Gangliosides in cultured neurons. Neurosci 5: 1647–1655.

    Article  CAS  Google Scholar 

  • Economo C and Koskinas GN (1925) Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen, Springer, Berlin.

    Google Scholar 

  • Filimonoff IN (1947) A rationale subdivision of the cerebral cortex. Arch Neurol Psychiat 58: 296–311.

    Article  PubMed  CAS  Google Scholar 

  • Irwin LN and Irwin CC (1982) Developmental changes and regional variation in the gangliosides composition of the rat hippocampus. Dev Brain Res 4: 481–485.

    Article  Google Scholar 

  • Jacobson M (1978) Developmental neurobiology, Plenum Press, New York.

    Book  Google Scholar 

  • Kostovic I and Molliver MW (1974) A new interpretation of the laminar development of cerebral cortex: synaptogenesis in different layers of the neopallium in the human fetus. Anat Rec 178, 395.

    Google Scholar 

  • Kracun I, Rösner H, Kostovic I, Rahmann H (1983) Areal and laminar distribution of gangliosides in the fetal human neopallium at 28 weeks of gestation. Roux’s Arch Dev Biol 192: 108–112.

    Article  Google Scholar 

  • Kracun I, Rösner H, Cosovic C, Stavljenic A (1984) Topographical atlas of the gangliosides of the adult human brain. J Neurochem 43: 979–989.

    Article  PubMed  CAS  Google Scholar 

  • Ledeen RW (1978) Ganglioside structures and distribution: are they located at nerve endings? J Supramolec Struct 8: 1–17.

    Article  CAS  Google Scholar 

  • Ledeen RW, Cochran FB, Yu RK, Samuels FG, Haley JE (1980) Gangliosides of the CNS myelin membrane. Adv Exp Biol Med 125: 167–176.

    Article  CAS  Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193: 265–275.

    PubMed  CAS  Google Scholar 

  • Martinez M, Ballabriga A (1978) A Chemical study on the development of the human forebrain and cerebellum during the growth spurt period. Gangliosides and plasmalogens. Brain Res 159: 351–362.

    Google Scholar 

  • Riboni L, Malesci A, Gaini SM, Sonnino S, Ghidoni R, Tettamanti G (1984) Ganglioside pattern of normal human brain, from samples obtained at surgery. A study especially referred to alkali labile species. J Biochem 96: 1943–1946.

    Google Scholar 

  • Rösner H (1977) Gangliosides, sialoglycoproteins and acetylcholinesterase of the developing mouse brain. Roux’s Arch Dev Biol 183: 325–335.

    Article  Google Scholar 

  • Rösner H (1980) A new thin-layer chromatographic approach for separation of multisialogangliosides. Analyt Biochem 109: 437–442.

    Article  PubMed  Google Scholar 

  • Rösner H (1982) Gangliosides changes in the chicken optic lobes as biochemical indicators of brain development and maturation. Brain Res 236: 46–61.

    Google Scholar 

  • Seyfried TN, Bernard DJ, Yu RK (1984) Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. J Neurochem 43: 1152–1162.

    Article  PubMed  CAS  Google Scholar 

  • Suzuki K (1965) The pattern of mammalian brain gangliosides. III. Regional and developmental differences. J Neurochem 12: 969–979.

    Article  CAS  Google Scholar 

  • Svennerholm L (1957) Quantitative estimation of sialic acids. Biochim biophys Acta 24: 604–611.

    Article  PubMed  CAS  Google Scholar 

  • Svennerholm L and Fredman P (1980) A procedure for quantitative isolation of brain gangliosides. Biochim Biophys Acta 617: 97–109.

    Article  PubMed  CAS  Google Scholar 

  • Vanier MT, Holm M, Ohmann R, Svennerholm L (1971) Developmental profiles of gangliosides in human and rat brain. J Neurochem 18: 581–592.

    Article  PubMed  CAS  Google Scholar 

  • Sidman RL and Rakic P (1973) Neuronal migration, with special references to developing human brain: A review. Brain Res 62: 1–35.

    Article  PubMed  CAS  Google Scholar 

  • Wieraszko A and Seifert W (1984) Evidence for a functional role of gangliosides in synaptic transmission: studies on rat brain striatal slices. Neurosci Lett 52: 123–128.

    Article  PubMed  CAS  Google Scholar 

  • Yu RK and Ando S (1980) Structures of some new complex gangliosides of fish brain. In: Svennerholm L, Dreyfus H, Urban P (eds): Structure and Function of Gangliosides, Plenum Press, New York, pp. 33–45.

    Chapter  Google Scholar 

  • Yusuf HKM, Merat A, Dickerson JWT (1977) Effect of development on the gangliosides of human brain. J Neurochem 28: 1299–1304.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Medical Faculty, Zagreb, Yugoslavia

    Ivica Kracun & Cedomir Cosovic

  2. Rebro, Neurobiochemical Laboratory, Clinical Hospital Center, Yugoslavia

    Ivica Kracun

  3. Institute of Zoology, University Hohenheim, Stuttgart, Federal Republic of Germany

    Harald Rösner

Authors
  1. Ivica Kracun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harald Rösner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cedomir Cosovic
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dipartimento di Chimica e Biochimica Medica, Facoltà di Medicina e Chirurgia, Università di Milano, Milano, Italy

    Guido Tettamanti

  2. Dept of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen

  3. Institut für Organische, Chemie und Biochemie, Universität Bonn, Bonn, Germany

    Konrad Sandhoff

  4. Dept of Biochemistry, University of Tokyo, Tokyo, Japan

    Yoshitaka Nagai

  5. Dept of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan

    Yoshitaka Nagai

  6. Research Laboratories, Fidia Neurobiological, Abano Terme, Italy

    Gino Toffano

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kracun, I., Rösner, H., Cosovic, C. (1986). Topographical Distribution of the Gangliosides in the Developing and Adult Human Brain. In: Tettamanti, G., Ledeen, R.W., Sandhoff, K., Nagai, Y., Toffano, G. (eds) Gangliosides and Neuronal Plasticity. FIDIA Research Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5309-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-5309-7_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-5311-0

  • Online ISBN: 978-1-4757-5309-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation