Early Recovery of Striatal Dopamine Uptake in Rats with Unilateral Nigro-Striatal Lesion Following Treatment with Monosialoganglioside
Evidence is accumulating that the central nervous system of the adult animal is capable of morphological, biochemical and functional recovery following injury (Cot-man et al., 1981; Freed et al., 1985). Gangliosides, which are normally present in neuronal membranes, seem to play a role in the events related to neuronal plasticity. In fact, the administration of purified gangliosides was shown to enhance the recovery processes after lesioning of the central and peripheral nervous system (Rapport and Gorio, 1981; Toffano et al., 1983; Agnati et al., 1983; Sabel et al., 1984a; Jonsson et al., 1984). It has been recently reported that after unilateral hemitransection of the nigro-striatal pathway in the rat, long-term treatment with GMI ganglioside stimulated the dopaminergic reinnervation in the striatum by enhancing the collateral sprouting of the nigro-striatal dopaminergic neurons (Toffano et al., 1983; 1984a; 1984b; Aldinio et al., 1984; Sabel et al., 1984b). The question arises whether the terminals of the nerve fibers regenerating under the action of gangliosides possess all the presynaptic characteristics of a “normal” striatal dopaminergic nerve terminal. In the present investigation we have studied the effect of repeated administration of monosialoganglioside inner ester on 3H-DA uptake activity in striatal synaptosomes after unilateral hemitransection of the nigro-striatal pathway.
KeywordsTyrosine Hydroxylase Lesion Side Saline Treated Animal Tyrosine Hydroxylase Activity Striatal Synaptosome
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