Acute Effects of Gangliosides on CNS Injury

  • Stephen E. Karpiak
  • Yu Shu Li
  • Paul Aceto
  • Sahebarao P. Mahadik
Part of the FIDIA Research Series book series (FIDIA, volume 6)


Recently investigators have focused their research efforts on exogenous ganglioside effects on processes associated with CNS injury. These CNS studies were prompted by reports that ganglioside-treatments enhance peripheral nerve regeneration after damage (Gorio et al., 1981; 1983), and that when gangliosides are added to some cell or tissue cultures, increased neurite outgrowth occurs (Ferrari et al., 1983; Leon et al., 1982; Roisen et al., 1981).


ATPase Activity Rotational Behavior Peripheral Nerve Regeneration Asymmetric Rotation Increase Neurite Outgrowth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



central nervous system


acetylcholine esterase


inner ester of ganglioside GM1.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Stephen E. Karpiak
    • 1
  • Yu Shu Li
    • 1
  • Paul Aceto
    • 1
  • Sahebarao P. Mahadik
    • 2
  1. 1.Division of NeuroscienceNew York State Phychiatric Institute, Departments of PsychiatryUSA
  2. 2.Biochemistry and Molecular Biophysics, College of Physicians & SurgeonsColumbia UniversityNew YorkUSA

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