Studies on the Involvement of Polyamines for the Trophic Actions of the Ganglioside GM1 in Mechanically and 6-hydroxydopamine Lesioned Rats. Evidence for a Permissive Role of Putrescine
In 1983 we were able to demonstrate for the first time that chronic ganglioside GM1 treatment in mechanically lesioned rats could partly counteract the retrograde cell body degeneration taking place in the central nervous system (CNS) following lesion. The system analyzed was the nigrostriatal dopamine (DA) system (Agnati et al., 1983; 1984a,b; Toffano et al., 1983, 1984; Fuxe and Agnati, 1984). In these experiments with partially hemitransected rats it was also possible to demonstrate that chronic ganglioside GM1 treatment could increase the synaptic function of DA, since following a three week treatment the ipsilateral amphetamine induced rotational behaviour in these rats was partly counteracted (Agnati et al., 1983). In the present paper these behavioural experiments have been countinued by studying the action of chronic GM1 treatment on water intake in partially hemitransected rats and also on the ipsilateral bias of such animals using a sensorimotor test battery.
KeywordsWater Intake Substantia Nigra Ornithine Decarboxylase Lesion Side Trophic Action
D,L α-difluoromethyl ornithine
central nervous system
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