Behavioral and Neurochemical Alterations Induced by Exogenous Gangliosides in Brain Damaged Animals: Problems and Perspectives

  • Gary L. Dunbar
  • William M. Butler
  • Barry Fass
  • Donald G. Stein
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Gangliosides are membrane glycosphingolipids and have a higher concentration within the nervous system than in any other tissue (Rapport, 1981). Although the function of gangliosides is not known, it has been proposed that they promote neural growth. Several lines of evidence support this proposal. For example, excessive accumulation of gangliosides during development results in the formation of meganeurites which possess dendritic-like growth cones (Purpura et al., 1978). Also, exogenous gangliosides enhance the survival of cells and neuritogenesis in vitro (e.g., Ferrari et al., 1983; Roisen et al., 1981).

Keywords

Rotational Behavior Behavioral Recovery Lateral Geniculate Nucleus Dorsalis Fetal Brain Tissue Lateral Septal Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

LSN

lateral septal nucleus

FF

fimbria-fornix

i.m.

intramuscular injection

SN

substantia nigra

i SN

ipsilateral substantia nigra

AC

midbrain angular complex

LGNd

lateral geniculate nucleus dorsalis

AGF2

inner ester of ganglioside GM1.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Gary L. Dunbar
    • 1
  • William M. Butler
    • 1
  • Barry Fass
    • 1
  • Donald G. Stein
    • 1
  1. 1.Brain Research Laboratory, Psychology DepartmentClark UniversityWorcesterUSA

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