Primary Neural Cell Cultures and GM1 Monosialoganglioside: A Model for Comprehension of the Mechanisms Underlying GM1 Effects in CNS Repair Process in Vivo

  • R. Dal Toso
  • D. Presti
  • D. Benvegnù
  • G. Tettamanti
  • G. Toffano
  • A. Leon
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Contrary to long-held pessimistic notions, it is now recognized that not only the developing but also the adult mammalian central nervous system (C.N.S.) is capable of undergoing a series of repair processes following injury. Although the irreversibly damaged neurons cannot be replaced, repair in the adult can partly be accomplished by additional growth and reorganization of neuronal processes from undamaged axons in response to adjacent axonal and synaptic degeneration. The intensity of this process varies with the extent, localization and type of neuronal injury and is presumably determined by appropriate signalling, i.e. neuronotrophic factors, from humoral surroundings, cell-cell contacts and denervated target areas. In at least some situations, a close correlation between lesion-induced remodeling and behavioral recovery has been reported (Nieto-Sampedro et al., 1983). Agents or conditions capable of enhancing the availability or activity of neuronotrophic factors are currently being examined in the attempt to ameliorate functional recovery of damaged CNS neuronal tissue.

Keywords

Gaba Uptake Adult Mammalian Brain Mesencephalic Cell Mesencephalic Dopaminergic Neuron Exogenous Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CNS

central nervous system

BME

Eagle’ls basal medium

PBS

phosphate buffered saline

DA

dopamine

THF

tetrahydro furan

GABA

γ-aminobutyric acid

DABA

L-2,4-diaminobutyric acid

BZT

benztropine-mesylate

GFAP

glial fibrillary protein

GIF

gloxylic acid induced fluorescence

DRG

dorsal root ganglia

NGF

nerve growth factor

PDGF

platelet derived growth factor.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • R. Dal Toso
    • 1
  • D. Presti
    • 1
  • D. Benvegnù
    • 1
  • G. Tettamanti
    • 2
  • G. Toffano
    • 1
  • A. Leon
    • 1
  1. 1.Fidia Neurobiological Research LaboratoriesAbano TermeItaly
  2. 2.Department of Medical Chemistry and BiochemistryUniversity of MilanoMilanoItaly

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