Metabolism of Exogenous GM1 and Related Glycolipids in the Rat

  • R. Ghidoni
  • M. Trinchera
  • B. Venerando
  • A. Fiorilli
  • G. Tettamanti
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Knowledge of the fate and metabolic pathways run by gangliosides administered to animals is interesting from both the pharmacological and biochemical points of view. Ceccarelli et al. (1976) and Obata et al. (1977) first discovered that exogenous gangliosides facilitate development of neuromuscular junctions in in vivo and in vitro systems. Since then many reports definitely established the ability of exogenous gangliosides to induce the formation of neurite-like processes in a number of neural cells cultivated in vitro, and to facilitate functional recovery of damaged peripheral and central nervous system by promoting neuronal survival, nerve regeneration and rein-nervation (for review see Ledeen, 1985). The molecular mechanisms underlying these effects are unknown and possibly connected with the physiological performances of the endogenous gangliosides.

Keywords

Golgi Apparatus Tritiated Water Chain Base Brain Ganglioside Neutral Glycolipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DPQ

dichloro-diciano benzo quinone

HPLC

high performance liquid chromatography

Sph

sphingosine

EDTA

ethylene diamino tetracetic acid

t.l.c.

thin layer chromatography.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • R. Ghidoni
    • 1
  • M. Trinchera
    • 1
  • B. Venerando
    • 1
  • A. Fiorilli
    • 1
  • G. Tettamanti
    • 1
  1. 1.Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and Biochemistry, The Medical SchoolUniversity of MilanMilanItaly

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