Axonal Transport of Gangliosides and Neutral Glycolipids in the Peripheral Nervous System. Identification of Ganglioside Types in Motoneurons of the PNS

  • D. A. Aquino
  • M. A. Bisby
  • R. W. Ledeen
Part of the FIDIA Research Series book series (FIDIA, volume 6)


The highly compartmentalized nature of ganglioside biosynthesis in cells (Yusef et al., 1983) together with their widespread distribution over the cell surface (Ledeen, 1978) has suggested the presence of efficient transport/transfer mechanisms. One aspect of these processes has been elucidated in the central nervous system (CNS) through demostration of fast axonal transport as the primary mechanism for conveyance of gangliosides to axonal and nerve-ending membranes (Forman and Ledeen, 1972; Rosner et al., 1973; Landa et al., 1979; Ledeen et al., 1981; Gammon et al., 1985). Recent studies with sciatic nerve of rabbit (Yates et al., 1984) and rat (Aquino et al., 1985a) have demonstrated similar anterograde flow of gangliosides in the PNS as well. The above rat system, involving motoneurons, also revealed another aspect of ganglioside movement in the neuron, i.e., retrograde axonal transport.


Sciatic Nerve Axonal Transport Retrograde Transport Sensory Axon Fast Axonal Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



central nervous system


peripheral nervous system




dorsal root ganglia








Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aquino DA, Bisby MA, Ledeen RW (1985a) J Neurochem 45: 1262–1267.PubMedCrossRefGoogle Scholar
  2. Aquino DA, Ledeen RW, Bisby MA (1985b) Trans Amer Soc Neurochem 16: 134.Google Scholar
  3. Bisby MA (1976) Exp Neurol 50: 628–640.PubMedCrossRefGoogle Scholar
  4. Bisby MA (1977) J Neurochem 28: 249–251.PubMedCrossRefGoogle Scholar
  5. Bisby MA (1980) In: Federoff S and Herz L (eds): Advances in Cellular Neurobiology. Academic Press, New York, pp. 69–117.Google Scholar
  6. Bulger VT and Bisby MA (1978) J Neurochem 31: 1411–1418.PubMedCrossRefGoogle Scholar
  7. Byrne MC, Ledeen RW, Roisen FJ, Yorke G, Sclafani JR (1983) J Neurochem 41: 1214–1222.PubMedCrossRefGoogle Scholar
  8. Byrne MC, Sbaschnig-Agler M, Aquino DA, Sclafani JR, Ledeen RW (1985) Anal Biochem 148: 163–173.PubMedCrossRefGoogle Scholar
  9. Forman DS and Ledeen RW (1972) Science 177: 630–633.PubMedCrossRefGoogle Scholar
  10. Gammon GM, Goodrum JF, Toews AD, Okabe A, Morell P (1985) J Neurochem 44: 376–387.PubMedCrossRefGoogle Scholar
  11. Landa CA, Maccioni HJF, Caputto R (1979) J Neurochem 33: 825–838.PubMedCrossRefGoogle Scholar
  12. Ledeen RW (1978) J Supramolec Struct 8: 1–17.CrossRefGoogle Scholar
  13. Ledeen RW (1983) In: Lajtha A (ed): Handbook of Neurochemistry. Vol. 3, Plenum Press, New York, pp. 41–90.Google Scholar
  14. Ledeen RW (1985) TINS 8: 169–174.Google Scholar
  15. Ledeen RW, Sbaschnig-Agler M, Pfenninger K (1985) Trans Amer Soc Neurochem 16: 266.Google Scholar
  16. Ledeen RW, Skrivanek JA, Nunez J, Sclafani JR, Norton WT, Farooq M (1981) In: Rapport MM and Gorio A (eds): Gangliosides in Neurological and Neuromuscular Function, Development, and Repair. Raven. Press, New York, pp. 211–223.Google Scholar
  17. Mansson J-E, Rosengren B, Svennerholm L (1985) J Chromatogr 322: 465–472.PubMedCrossRefGoogle Scholar
  18. Rosner H, Wiegandt H, Rahmann H (1973) J Neurochem 21: 655–665.PubMedCrossRefGoogle Scholar
  19. Vance DE and Sweeley CC (1967) J Lipid Res 8: 621–630.PubMedGoogle Scholar
  20. Williams MA and McCluer RH (1980) J Neurochem 35: 266–269.PubMedCrossRefGoogle Scholar
  21. Yamamoto M, Boyer AM, Schwarting G (1985) Proc Natl Acad Sci USA 82: 3045–3049.PubMedCrossRefGoogle Scholar
  22. Yates AJ, Tipnis UR, Hofteig JH, Warner JK (1984) In: Ledeen R, Yu RK, Rapport MM, Suzuki K (eds): Ganglioside Structure, Function and Biomedical Potential. Plenum Press, New York, pp. 155–168.CrossRefGoogle Scholar
  23. Yusuf HKM, Pohlentz G, Schwarzmann G, Sandhoff K (1984) J Neurosci Res 12: 161–178.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. A. Aquino
    • 1
  • M. A. Bisby
    • 1
    • 2
  • R. W. Ledeen
    • 1
  1. 1.Departments of Neurology and BiochemistryAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Medical PhysiologyUniversity of CalgaryAlbertaCanada

Personalised recommendations