Abstract
For a long time it has been suggested that gangliosides can somehow modulate synaptic transmission (Svennerholm, 1980; Rahmann, 1983). However, the experimental proof is still missing. It was demonstrated over 20 years ago that gangliosides help neuronal tissue to recover from the transient exposure to cold (Balakrishman and McIlwain, 1961; McIlwain, 1961). In the last 10 years functional studies on gangliosides concentrated mainly on the neurotrophic effects of gangliosides in nerve cell cultures (Morgan and Seifert, 1979; Seifert, 1981) and on the potential influence of gangliosides on the reinnervation processes in the nervous system (Ledeen, 1984). Surprisingly, very little effort has been made to test the hypothesis put forward for the first time by Svennerholm (1963, 1980) and later in more detailed form by Rahmann et al. (1976) concerning participation of gangliosides in neurotransmission. Our study is addressed directly to this problem.
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Abbreviations
- NVCh:
-
Neuraminidase from Vibrio Cholerae
- NAu:
-
Neuraminidase from Arthrobacter Ureafaciens
- RR:
-
Ruthenium Red
- ChT:
-
Cholera Toxin
- TT:
-
Tetanus Toxin
- anti-GM1:
-
Antiserum against ganglioside GM1
- AP:
-
3,4-diamino-pyridine
- LTP:
-
Long Term Potentiation.
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Wieraszko, A., Seifert, W. (1986). Involvement of Gangliosides in the Synaptic Transmission in the Hippocampus and Striatum of the Rat Brain. In: Tettamanti, G., Ledeen, R.W., Sandhoff, K., Nagai, Y., Toffano, G. (eds) Gangliosides and Neuronal Plasticity. FIDIA Research Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5309-7_12
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DOI: https://doi.org/10.1007/978-1-4757-5309-7_12
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