An Hypothesis on the Role of Pteroylpolyglutamate Derivatives as Coenzymes

  • Roy L. Kisliuk
  • Yvette Gaumont
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 163)


Evidence is assembled supporting the view that the poly-γ-Glu chain of pteroyl poly-γ-Glu derivatives plays a role in coordinating the activities of enzymes involved in the sequential metabolism of single carbon units.


Basic Group Unpublished Work Inhibition Pattern Anchor Protein Rate Intermediate 
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  1. 1.
    Wilson, I. B., Fed. Proc., 18, 752–758 (1959).PubMedGoogle Scholar
  2. 2.
    Kisliuk, R. L., Gaumont, Y., Baugh, C. M., Galivan, J. H., Maley, G. F., and Maley, F., in: Chemistry and Biology of Pteridines (R. L. Kisliuk and G. M. Brown, eds.), pp. 431–435, Elsevier-North Holland, New York (1979).Google Scholar
  3. 3.
    Crusberg, T. C., Leary, R. P., and Kisliuk, R. L., J. Biol. Chem., 245, 5292–5296 (1970).PubMedGoogle Scholar
  4. 4.
    Kisliuk, R. L., Gaumont, Y., Lafer, E., Baugh, C. M., and Montgomery, J. A., Biochemistry, 20, 929–934 (1981).PubMedCrossRefGoogle Scholar
  5. 5.
    Daron, H. H., and Aull, J. L., J. Biol. Chem., 253, 940–945 (1978).PubMedGoogle Scholar
  6. 6.
    Danenberg, P. V., and Danenberg, K., Biochemistry, 17, 4018–4024 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    MacKenzie, R. E., and Baugh, C. M., Biochim. Biophys. Acta, 611, 187–195 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    Tan, L. U. L., Drury, E. J., and MacKenzie, R. E., J. Biol. Chem., 252, 1117–1122 (1977).PubMedGoogle Scholar
  9. 9.
    Paukert, J. L., D’Ari-Strauss, L., and Rabinowitz, J. C., J. Biol. Chem., 251, 5104–5111 (1976).PubMedGoogle Scholar
  10. 10.
    Caperelli, C. A., Benkovic, P. A., Chettur, G., and Benkovic, S. J., J. Biol. Chem., 255, 1885–1890 (1980).PubMedGoogle Scholar
  11. 11.
    Smith, G. K., Mueller, W. T., Wasserman, G. F., Taylor, W. D., and Benkovic, S. J., Biochemistry, 19, 4313–4321 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    Ferone, R., and Roland, S., Proc. Nat. Acad. Sci. USA, 77, 5082–5806 (1980).CrossRefGoogle Scholar
  13. 13.
    Reddy, G. P. V., and Mathews, C. K., J. Biol. Chem., 253, 3461–3466 (1978).PubMedGoogle Scholar
  14. 14.
    Reddy, G. P. V., and Pardee, A. B., Proc. Nat. Acad. Sci. USA, 77, 3312–3316 (1980).CrossRefGoogle Scholar
  15. 15.
    Kovacs, J., Kapoor, U. R. G., Mayers, G. L., Giannasio, V. R., Gianotti, R., Senyk, G., Nitecki, E., and Goodman, J. W., Biochemistry, 11, 1953–1958 (1972).PubMedCrossRefGoogle Scholar
  16. 16.
    Maley, G. F., Maley, F., and Baugh, C. M., J. Biol. Chem., 254, 7485–7487 (1979).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Roy L. Kisliuk
    • 1
  • Yvette Gaumont
    • 1
  1. 1.Department of Biochemistry and PharmacologyTufts University School of MedicineBostonUSA

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