Regulation of Lipoprotein Metabolism in HepG2 Cells by Citrus Flavonoids

  • Elzbieta M. Kurowska
  • John A. Manthey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 505)


Elevated levels of blood cholesterol are known to be one of the major risk factors associated with coronary heart disease (CHD), the leading cause of death in North America. The association is largely due to the importance of cholesterol, especially low-density lipoprotein (LDL) cholesterol, in the formation and development of atherosclerotic plaque, the underlying pathological condition of CHD. Dietary intervention has been proven to play an important role in prevention and treatment of hypercholesterolemia. Common dietary strategies aimed to lower high blood cholesterol include reduced intake of dietary saturated fat and cholesterol and increased intake of fiber (Connor and Connor, 1998). Recently, many reports have proposed another approach: increased intake of certain food components and food products with cholesterol-lowering potential (Cook and Samman, 1996).


HepG2 Cell Cholesteryl Ester Orange Juice Grapefruit Juice Concentration Of25 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Elzbieta M. Kurowska
    • 1
  • John A. Manthey
    • 2
  1. 1.KGK Synergize, Inc.LondonCanada
  2. 2.Agricultural Research Service, Citrus and Subtropical Products LaboratoryU. S. Department of AgricultureWinter HavenUSA

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