Human 17β-Hydroxysteroid Dehydrogenase Type 5 is Inhibited by Dietary Flavonoids

  • A. Krazeisen
  • R. Breitling
  • G. Möller
  • J. AdamskiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 505)


Phytoestrogens contained in a vegetarian diet are supposed to have beneficial effects on the development and progression of a variety of endocrine-related cancers. We have tested the effect of a variety of dietary phytoestrogens, especially flavonoids, on the activity of human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD 5), a key enzyme in the metabolism of estrogens and androgens. Our studies show that reductive and oxidative activity of the enzyme are inhibited by many compounds, especially zearalenone, coumestrol, quercetin and biochanin A. Among flavones, inhibitor potency is enhanced with increased degree of hydroxylation. The most effective inhibitors seem to bind to the hydrophilic cofactor binding pocket of the enzyme.


Glycyrrhetinic Acid Abietic Acid Dehydrogenase Type Hydroxysteroid Dehydrogenase Dietary Phytoestrogens 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • A. Krazeisen
  • R. Breitling
  • G. Möller
  • J. Adamski
    • 1
    Email author
  1. 1.GSF-National Research Center for Environment and Health, Institute for Experimental GeneticsGenome Analysis CenterNeuherbergGermany

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