Flavonoids in Cell Function

  • John A. Manthey
  • Béla S. Buslig
  • Michael E. Baker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 505)

Abstract

Flavonoids (and isoflavonoids) are a large subgroup of secondary metabolites categorized as phenolics or polyphenols. Their wide distribution in the plant kingdom and prokaryotes, and the exceptional variety of these compounds, over 4000 have been identified so far, contributed to the attractiveness for study by chemists, geneticists, taxonomists and investigators in numerous other areas. The early investigators concentrated primarily on the purification and identification of these compounds. The studies of chemical structures of phenolics and their biochemical interrelations eventually expanded to cover the area of classification, leading to a distinct field of chemical or biochemical taxonomy. This approach greatly aided and often clarified classification schemes based on traditional methods relying on morphology, and later, genetic studies. The literature dealing with the chemistry, biochemistry and related aspects of flavonoids is extensive. This volume is not intended to be an exhaustive reference on flavonoids. Excellent information on these compounds can be found in numerous compilations of the chemistry, isolation and other techniques (Geissman,1962; Harborne, 1967; Mabry et al., 1970; Harborne et al., 1975; Harborne and Baxter, 1999).

Keywords

Xanthine Oxidase Adenosine Receptor Pollen Germination Liquid Chromatography Couple With Mass Spectrometry Specific Adhesion Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ames, B. N., Gold, L. S., and Willet, W. C., 1995, The causes and prevention of cancer. Proc. Natl. Acad. Sci.Google Scholar
  2. Arnold, J. T., Wilkinson, B. P., Sharma, S., and Steele, V. E., 1995, Evaluation ofchemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay, Cancer Research 55: 537–543.Google Scholar
  3. Baker, M. E., 1998, Flavonoids as hormones: A perspective from the analysis of molecular fossils, In: Flavonoids in the Living System, Manthey, J. A. and Buslig, B. S., eds., Plenum Press, New York and London, pp. 249–267.CrossRefGoogle Scholar
  4. Barnes, K. A., Smith, R.A., Williams, K., Damant, A.P., and Shepherd, M. J., I 998a, A microbore high performance liquid chromatography/electrospray ionization mass spectrometry method for the determination of the phytoestrogens genistein and daidzein in comminuted baby foods and soya flour, Rapid Commun. Mass Spectrom. 12: 130–138.Google Scholar
  5. Block, G., Patterson, B., and Subar, A., 1992, Fruit, vegetables and cancer prevention: a review of the epidemiologic evidence. Nutr. Cancer 18, 1–29.Google Scholar
  6. Cimino, C. O., Shelnutt, S. R., Ronis, M. J. J., and Badger, T. M., 1999, An LC-MS method to determine concentrations of isoflavones and their sulfate and glucuronide conjugates in urine, Clin. Chico. Acta 287: 69–82.CrossRefGoogle Scholar
  7. Doerge, D. R., Chang, H. C., Churchwell, M. 1., and Holder, C. L., 2000, Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry, Drug Metab. Disp. 28: 298–307.Google Scholar
  8. Furuya, M., Galston, A. W., and Stowe, B. B., 1962, Isolation from peas of cofactors and inhibitors of indolyl-3-acetic acid oxidase, Nature 193: 456–457.CrossRefGoogle Scholar
  9. Galston, A. W., 1969, Flavonoids and photomorphogenesis in peas, In Perspectives in Phytochemistry, Harborne, J. B., and Swain, T., eds., Academic Press, New York., pp. 193–204.Google Scholar
  10. Geissman, T. A., 1962, The Chemistry of Flavonoid Compounds, Macmillan, New York.Google Scholar
  11. Harborne, J. B., 1967, Comparative Biochemistry of the Flavonoids, Academic Press, New York.Google Scholar
  12. Harborne, J. B., and Baxter, H., eds., 1999, The Handbook of Natural Flavonoids,2 vols., CHIPS Books, 1800 pp.Google Scholar
  13. Harborne, J. B., Mabry, T. J., and Mabry, H., 1975, The Flavonoids, Chapman and Hall, London.Google Scholar
  14. Hodnick, W. F., Ahmad, S., and Pardini, R. S., 1998, Induction of oxidative stress by redox active flavonoids, In: Flavonoids in the Living System, Manthey, J. A. and Buslig, B. S., eds., Plenum Press, New York and London, pp. 131–150.CrossRefGoogle Scholar
  15. Holder, C. L., Churchwell, M. I., and Doerge, D. R., 1999, Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS, J. Agric. Food Chem. 47: 3764–3770.CrossRefGoogle Scholar
  16. Jacobs, M., and Rubery, P. H., 1988, Naturally occurring auxin transport regulators, Science 241:346–349.Google Scholar
  17. Mabry, T. J., Markham, K. R., and Thomas, M. B., 1970, The Systematic Identification of Flavonoids, Springer-Verlag, New York.CrossRefGoogle Scholar
  18. Manthey, J. A., and Buslig, B. S., eds., 1998, Flavonoids in the Living System, Plenum Press, New York and London. Rusznyâk, S. and Szent-Györgyi, A., 1936, Vitamin P: flavonols as vitamins, Nature 27: 138.Google Scholar
  19. Shelnutt, S. R., Cimino, C. O., Wiggins, P. A, and Badger, T. M., 2000, Urinary pharmacokinetics of the glucuronideGoogle Scholar
  20. and sulfate conjugates of genistein and daidzein, Cancer Epidem. Biomark. Prevent. 9:413–419.Google Scholar
  21. Steinmetz, K. A., and Potter, J. D., 1991, Vegetables, fruit, and cancer. I: Epidemiology. Cancers Causes Control 2, 325–357.CrossRefGoogle Scholar
  22. Stevens, J. F., Taylor, A.W., and Deinzer, M.L., 1999, Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry, J. Chromatogr. A 832:97–107.Google Scholar
  23. Vierheilig, H., Bago, B., Albrecht, C., Poulin, M.-J., and Piché, Y., 1998, Flavonoids and arbuscular-mycorrhizal fungi, In: Flavonoids in the Living System, Manthey, J. A. and Buslig, B. S., eds., Plenum Press, New York and London, pp. 9–33.CrossRefGoogle Scholar
  24. Vinson, J. A., 1998, Flavonoids in foods as in vitro and in vivo antioxidants, In: Flavonoids in the Living System Google Scholar
  25. Manthey, J. A. and Buslig, B. S., eds., Plenum Press, New York and London, pp. 151–164.Google Scholar
  26. Winkel-Shirley, B., 2001, Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology, Plant Physiol. 126: 485–493.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • John A. Manthey
    • 1
  • Béla S. Buslig
    • 1
  • Michael E. Baker
    • 2
  1. 1.U.S. Department of AgricultureCitrus and Subtropical Products LaboratoryWinter HavenUSA
  2. 2.Department of Medicine, 0623BUniversity of California, San DiegoLa JollaUSA

Personalised recommendations