Refixation of Solubilized and Purified Microsomal Enzymes: Towards an Extracorporal Detoxification in Liver Failure

  • G. Brunner
  • H. Lösgen


Few attempts have been made to solubilize and purify membrane bound enzymes with the aim of refixation to artificial carriers. The main reason is that after solubilization membrane bound enzymes are often less stable due to a loss of natural environment or cofactors and consequently do not allow lengthy steps of purification.


Liver Failure Microsomal Enzyme Microsomal Membrane Hydroxylation Activity Multienzyme Complex 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • G. Brunner
    • 1
  • H. Lösgen
    • 1
  1. 1.Department of Gastroenterology and Metabolic DiseasesUniversity of GottingenW. Germany

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