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Analytical and Biomedical Applications of Immobilized Enzymes: A Review

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Enzyme Engineering

Abstract

The aim of this review is to cover two related topics which differ to a large extent in their aims and their operating conditions. Since these proceedings provide several papers of a specialized session in these topics which allow specialists in the field to become aware of new technical solutions, this review will restrict itself to an analysis of the constraining factors, of the technical solutions and of remaining problems. Each of these aspects is illustrated as far as possible by one or several published works in the field. Concerning the analytical applications, quantitative analysis will be considered exclusively. Excluded will be any reference to qualitative analyses, such as the use of immobilized enzymes as a ligand in affinity chromatography, for example. With regard to medical aspects these were reviewed during the previous Enzyme Engineering Conference (1). Therefore, only the more recent work will be discussed.

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References

  1. BROUN, G. In “Enzyme Engineering Vol 2” (Eds. E.K. Pye and L.B. Wingard, Jr.) Plenum Press, New York, 1974, p. 433.

    Book  Google Scholar 

  2. WARBURG, 0., CHRISTIAN, W. Biochem. Z. 287: 291, 1936.

    Google Scholar 

  3. GREDDES, L.A., BAKER, L.E. “Principles of Applied Biomedical Instrumentation”, John Wiley, New York, 1968.

    Google Scholar 

  4. CLARK, L.C.,, LYONS, C. Ann. N.Y. Acad Sci. Z02: 29, 1962.

    Google Scholar 

  5. UPDIKE, S.J., HICKS, G.P. Nature 214: 986, 1967.

    Article  Google Scholar 

  6. MONTALVO, J.G., GUILBAULT, G.G. Anal. Chem. 41: 1897, 1969.

    Article  Google Scholar 

  7. TRAN-MINH, C., BROUN, G.B. Anal. Chem. 47: 1359, 1975.

    Article  Google Scholar 

  8. AIZAWA, M., KARUBE, I., SUZUKI, S. Anal. Chin. Acta. 69: 431, 1975.

    Article  Google Scholar 

  9. HORNBY, W.E., FILIPUSON, H. Biochem. Biophys. Acta 220: 343, 1970.

    Article  Google Scholar 

  10. WEIBEL, M.K., DRITSCHILO, W., BRIGHT, H.J., HUMPHREY, A. E. Anal. Biochem. 52: 402, 1973.

    Article  Google Scholar 

  11. MORRIS, D.L., CAMPBELL, J., HORNBY, W. E. Biochem. J. Z47: 593, 1975.

    Google Scholar 

  12. INMAN, D.S., HORNBY, W. E. Biochem. J. Z37: 25, 1973.

    Google Scholar 

  13. GUILBAULT, G.G., STOCKBRO, W. Anal. Chin. Acta. 76: 237, 1975.

    Article  Google Scholar 

  14. GUILBAULT, G.G. In “Enzyme Engineering,Vol 2”, (Eds. E.K. Pye, L. B. Wingard, Jr.) Plenum Press, New York, 1974, p. 377.

    Book  Google Scholar 

  15. MARCONI, W. In “Industrial Aspects of Biochemistry” (Ed. B. Spencer) FEBS, 1974, p. 139.

    Google Scholar 

  16. WILLIAMS, D.L., DOIG, A.R., KOROSI, A. Anal. Chem. 42: 118, 1970.

    Article  Google Scholar 

  17. SCHLAPFER, P., MINDT, W., RACINE, P. Clin. Chin. Acta. 57: 283, 1974.

    Article  Google Scholar 

  18. LLENADO, R.A., RECHNITZ, G.A. Anal. Chem. 45: 2165, 1973.

    Article  Google Scholar 

  19. LAHODA, E.J.J., LIU, C.C., WINGARD, L.B. Jr. Intern. Energy Conversion Engin. Conf. Proceedings, 740–744, 1972.

    Google Scholar 

  20. NAGY, G., VON STORP, L.H., GUILBAULT, G.G. Anal. Chin. Acta. 66: 443, 1973.

    Article  Google Scholar 

  21. NILSSON, H., AKERLUND, A.C., MOSBACH, K. Biochim. Biophy. Acta. 320: 529, 1973.

    Article  Google Scholar 

  22. DRITSCHILO, W., WEIBEL, M.K. Biochem. Med. 9: 32, 1974.

    Article  Google Scholar 

  23. CLARK, L.C. Jr.,, CLARK, E.W. In “Oxygen Transport to Tissue” (Eds. H.I. Bicher and D.F. Bryley) Plenum Press, New York, 1973, p. 127.

    Google Scholar 

  24. CLARK, L.C. Jr., EMORY, C. In “Ion Selective Electrodes and Enzyme Selective Electrodes” (Ed. M. Kesseler). In the press.

    Google Scholar 

  25. GUILBAULT, G.G., LUBRANO, G. J. Anal. Chin. Acta. 69: 189, 1974.

    Article  Google Scholar 

  26. NANJO, M., GUILBAULT, G.G. Anal. Chem. 46: 1769, 1974.

    Article  Google Scholar 

  27. DRITSCHILO, W., WEIBEL, M.K. Biochem. Med. ZZ: 242, 1974.

    Google Scholar 

  28. GUILBAULT, G.G., HRABANKOVA, E. Analyt. Chem. 41: 1779, 1970.

    Article  Google Scholar 

  29. NANJO, M., GUILBAULT, G.G. Anal. Chin. Acta. 73: 367, 1974.

    Article  Google Scholar 

  30. GUILBAULT, G.G., LUBRANO, G.S. Anal. Chin. Acta. 69: 188, 1974.

    Google Scholar 

  31. DAVIES, P., MOSBACH, K. Biochim. Biophys. Acta, 370: 329, 1974.

    Article  Google Scholar 

  32. GUILBAULT, G.G., ZIMMERMAN, R.L. Anal. Chin. Acta. 69: 183, 1972.

    Article  Google Scholar 

  33. IKEDO, S., FUKURI, S. FEBS Lett. 41: 216, 1974.

    Article  Google Scholar 

  34. RECHNITZ, G.A., LLENADO, R. Anal. Chem. 43: 283, 1971.

    Article  Google Scholar 

  35. LLENADO, R.A., RECHNITZ, G.A. Anal. Chem. 43: 1457, 1971.

    Article  Google Scholar 

  36. LECOQ, D., HERVAGAULT, J.F., BROUN, G., JOLY, G., KERNEVEZ, J.P., THOMAS, D. J. Biol. Chem. 250: 5496, 1975.

    Google Scholar 

  37. AIZAWA, M., KARUBE, I., SUZUKI, S. AnaZ. Chim. Acta. 69: 431, 1974.

    Article  Google Scholar 

  38. CULLEN, L.F., RUSLING, J.F., SCHLEIFER, A., PAPARELLO, G.J. Anal. Chem.46:1955, 1974.

    Google Scholar 

  39. BAUMAN, E.K., GOODSON, L.H., GUILBAULT, G.G., KRAMER, D. N. Anal. Chem. 37: 1378, 1965.

    Article  Google Scholar 

  40. GOODSON, L.H., JACOBS, W.B., DAVIES, A.W. AnaZ. Biochem. 51: 362, 1972.

    Article  Google Scholar 

  41. GUILBAULT, R.A., KRAMER, D. N. AnaZ. Chem. 37: 1675, 1965.

    Article  Google Scholar 

  42. LOVETT, S. AnaZ. Biochem. 64: 110, 1975.

    Article  Google Scholar 

  43. GUILBAULT, G.G., SMITH, R.K., MONTALVO, J.G. Jr. AnaZ. Chem. 41: 600, 1969.

    Article  Google Scholar 

  44. JOHANSSON, A., LUNDBERG, J., MATTIASON, B., MOSBACH, K. Biochim. Biophys. Acta. 304:217, 1973.

    Google Scholar 

  45. MOSBACH, K., DANIELSSON, B. Biochim. Biophys. Acta. 364: 140, 1974.

    Article  Google Scholar 

  46. TRAN-MINH, C., SELEGNY, E., BROUN, G. C.R. Acad. Sci., Paris, 275 (C): 309, 1972.

    Google Scholar 

  47. MONTALVO, J. Jr. AnaZ. Chem. 4Z: 2093, 1969.

    Article  Google Scholar 

  48. GUILBAULT, G.G., NAGY, G., KUAN, S.S. AnaZ. Chim. Acta. 67: 195, 1973.

    Article  Google Scholar 

  49. GUILBAULT, G.G., NAGY, G. AnaZ. Chem. 45: 417, 1973.

    Article  Google Scholar 

  50. GUILBAULT, G.G., TARP, M. AnaZ. Chim. Acta. 73: 355, 1974.

    Article  Google Scholar 

  51. BOOKER, H. E. Diss. Abst. Int. B. AnaZ. Chem. 3135; 1973.

    Google Scholar 

  52. HANSEN, E.H., RUSICKA, J. Anal. Chim. Acta. 72: 353, 1974.

    Article  Google Scholar 

  53. ANFALT, T., GRANELLI, A., JAGNER, P. AnaZ. Lett. 6: 969, 1973.

    Article  Google Scholar 

  54. BERJONNEAU, A.M., THOMAS, D., BROUN, G.B. Path.497 Biol. 22: 497, 1974.

    Google Scholar 

  55. GUILBAULT, G.G., SHU, F.R. Anal. Chem. 44: 2161, 1973.

    Article  Google Scholar 

  56. LLENADO, R.A., RECHNITZ, G.A. Anal. Chem. 44: 468, 1972.

    Article  Google Scholar 

  57. MELL, L.D., MALLOY, J.T. Anal. Chem. 47: 299, 1975.

    Article  Google Scholar 

  58. CLARK, L. C.Jr. Personal communication.

    Google Scholar 

  59. BESMAN, J.P., SCHULTZ, R.P. Trans. Am. Soc. Artif. Intern. Organs, Z9: 361, 1973.

    Google Scholar 

  60. POZNANSKY, M.J., CHANG, T.M.S. Biochim. Biophys. Acta. 334: 103, 1974.

    Article  Google Scholar 

  61. GREGORIADIS, G., RYMAN, B. E. European J. Biochem. 24: 485, 1972.

    Article  Google Scholar 

  62. GREGORIADIS, G. FEES Lett. 36: 292, 1973.

    Article  Google Scholar 

  63. PAILLOT, B., REMY, M.H., THOMAS, D., BROUN, G. Path. Bioi. 22: 491, 1974.

    Google Scholar 

  64. ALLISON, J.P., DAVIDSON, L. GUILERREZ-HARTMAN, A., KITTO, B. Biochem. Biophys. Res. Corrunun. 47: 66, 1972.

    Article  Google Scholar 

  65. HYDEN, H., GELIN, L.E., LARSSON, S., SAARNE, A. Rev. Surgery, 31: 305, 1974.

    Google Scholar 

  66. KUSSEROW, B.K., LARROW, R.N., NICHOLS, J. E. Trans. Am. Soc. Artif. Intern. Organs, 19: 8, 1973.

    Article  Google Scholar 

  67. NEERUNJUN, D.E., GREGORIADIS, G. Biochem. Soc. Trans. 2: 868, 1974.

    Google Scholar 

  68. VENTER, J.C., VENTER, B.R., DIXON, J.E., KAPLAN, N.O. Biochem. Med. 12: 79, 1975.

    Article  Google Scholar 

  69. GREGORIADIS, G., ALLISON, A.C. FEBS Lett. 45:71, 1974.

    Google Scholar 

  70. KIM, S.W., LEE, R.G., OSTER, H., COLEMAN, D., ANDRADE, J.D., LENTZ, D.J., OLSEN, D. Trans. Am. Soc. Artif. Intern. Organs, 20: 449, 1974.

    Google Scholar 

  71. THOMAS, D., LAWNY, F., CORDONNIER, M., CHAPOT, D. In manuscript.

    Google Scholar 

  72. GUIDOIN, R.G., AWAD, J.A., BRASSARD, A., DOMURADO, D., BROUN, G.B., THOMAS, D. Biomat. Med. Dey. Art. Org. 2: 301, 1974.

    Google Scholar 

  73. DOMURADO, D., THOMAS, D., BROUN, G.B. J. Biomed. Mater. Res. 8: 109, 1974.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Université de Technologie de Compiegne, Compiegne, France

    G. B. Broun

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  1. G. B. Broun
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    E. Kendall Pye

  2. Research and Development Labs, Corning Glass Works, Corning, New York, USA

    Howard H. Weetall

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Broun, G.B. (1978). Analytical and Biomedical Applications of Immobilized Enzymes: A Review. In: Pye, E.K., Weetall, H.H. (eds) Enzyme Engineering. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5163-5_43

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  • DOI: https://doi.org/10.1007/978-1-4757-5163-5_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5165-9

  • Online ISBN: 978-1-4757-5163-5

  • eBook Packages: Springer Book Archive

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