Abstract
It has been recognized that gram-negative bacteriaemia is the major cause of hospital sepsis. The pathology of gram-negative sepsis is attributed to endotoxin. Endotoxins of all gram-negative bacteria have the same lipid moiety, so called lipid A, which is thought to be responsible for its pathogenic effects (6). Gram-negative endotoxaemia leads to an irreversible cardiovascular collapse (shock), acute pulmonary insufficiency, and disseminated vascular coagulation syndrome that can result in lethality up to 60–80%, despite antibiotic therapy (2). This prompted the search for immunotherapeutic approaches to the protection against gram-negative sepsis (1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baumgartner, J.-D., McCutchan, J. A., van Melle, G., Vogt, M., Luethy, R., Glauser, M. P., Ziegler, E. J., Klauber, M. R., Muehlen, E., Chiolero, R. and Geroulanos, S., 1985, Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid. Lancet ii: 59.
Finland, M., 1980, Changing ecology of bacterial infection as related to antibacterial therapy. J. Infect. Dis. 122: 419.
Galanos, G., Luderitz, O. and Westphal, O., 1969, A new method for the extraction of R lipopolysaccharides. Eur. J. Biochem. 9: 245.
Galfre, G., Milstein, C. and Wright, B., 1979, Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG. Nature 277: 131.
Kohler, G. and Milstein, C., 1975, Continuous culture of fused cells secreting antibody of predetermined specificity. Nature 256: 495.
Morrison, D. C. and Ulevitch, R. J., 1978, The effects of Bacterial Endotoxins on Host Mediation Systems. Amer. J. Pathol. 93(2): 526.
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F. and Cerami, A., 1987, Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 300: 662.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Shnyra, A.A. et al. (1990). Monoclonal Antibody to Lipid a Prevents the Development of Haemodynamic Disorders in Endotoxemia. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_63
Download citation
DOI: https://doi.org/10.1007/978-1-4757-5140-6_63
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-5142-0
Online ISBN: 978-1-4757-5140-6
eBook Packages: Springer Book Archive