Endotoxin pp 641-652 | Cite as

Lipid a Precursors Protect Against Endotoxin Challenge

  • R. A. Proctor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Gram-negative bacteremia, when accompanied by shock, carried a 20–75 percent mortality (4, 23, 26). The advent of more active antibiotics and improved supportive therapy such as fluids, respirators and pressors have benefitted many patients, but the mortality rate remains high in spite of the best therapy (4, 23, 26). This has led to the search for further therapies such as high dose glucocorticoids (19, 20, 42, 43), narcotic antagonists (18, 21) and prostacycline infusion (11, 14). Although these approaches proved exciting in animal models, they have not come into widespread clinical use (13, 42, 43).


Protective Efficacy Endotoxin Tolerance High Dose Glucocorticoid Monophosphoryl Lipid Endotoxin Challenge 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. A. Proctor
    • 1
  1. 1.Department of Medical Microbiology and Department of MedicineUniversity of Wisconsin Medical SchoolMadisonUSA

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