Endotoxin pp 593-601 | Cite as

Alterations of Responses to Bacterial Endotoxin by Bacteroides Fragilis in Vivo and in Vitro

  • A. C. Rodloff
  • S. Ehlers
  • D. K. Blanchard
  • H. Hahn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Gram negative obligately anaerobic bacteria constitute a major part of the normal indigenous bacterial flora of humans, however, they also have to be considered to be important opportunistic pathogens, e.g., infections with Bacteroidaceae may arise, when the function of the mucous membranes as anato­mic barrier for microorganisms is compromised and bacteria are introduced into otherwise sterile tissues. In such instances, the resulting infection is often of polymicrobial etiology and Bacteroidaceae are found especially in association with Enterobacteriaceae. It is clinical experience that these mixed aerobic/anaerobic infections create significant therapeutical problems even if the individual causative microorganisms display a high in-vitro­susceptibility to antimicrobial agents employed. Therefore, efforts were made to study the interaction of aerobes and anaerobes in mixed infections with a number of different animal models.


Spleen Cell Infected Mouse Listeria Monocytogenes Post Infection Bacteroides Fragilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Altemeier, W.A., 1942, The pathogenicity of the bacteria of appendicitis peritonitis. Surgery 11: 374–384.Google Scholar
  2. 2.
    Dijkmans, B. A. C., Leijh, P. C. J., Braat, A. G. P. and van Furth, R., 1985, Effect of bacterial competition on the opsonisation, phagocytosis, and intracellular killing of microorganisms by granulocytes. Infect. Immun. 49: 219–224.Google Scholar
  3. 3.
    Hite, K. E., Locke, M. and Hesseltine, H. C., 1949, Synergism in experimental infections with nonsporulating anaerobic bacteria. J. Infect. Dis. 84: 1–9.Google Scholar
  4. 4.
    Ingham, H. R., Sissons, P. R., Thargonnet, D., Selkon, J. B. and Codd, A. A., 1977, Inhibition of phagocytosis in vitro by obligate anaerobes. Lancet II 1252–1254.Google Scholar
  5. 5.
    Jones, G. R. and Gemmel, C. G., 1982, Impairment by Bacteroides species of opsonisation and phagocytosis of enterobacteria. J. Med. Microbiol. 15: 351–361.Google Scholar
  6. 6.
    Kelly, M. J., 1978, The quantative and histological demonstration of pathogenic synergy between Escherichia coli and Bacteroides fragilis in guinea pig wounds. J. Med. Microbiol. 11: 513–523.Google Scholar
  7. 7.
    Mayrand, D. and McBride, B. C., 1980, Ecological relationship of bacteria involved in a simple, mixed anaerobic infection. Infect. Immun. 27: 44–50.Google Scholar
  8. 8.
    Onderdonk, A. B., Bartlett, J. G., Louie, T., Sullivan-Seigler, N. and Gorbach, S. L., 1976, Microbial synergy in experimental intra-abdominal abscess. Infect. Immun. 13: 22–26.Google Scholar
  9. 9.
    Rodloff, A. C., Becker, J., Blanchard, D. K., Klein, T. W., Hahn, H. and Friedman, H., 1986, Inhibition of macrophage phagocytosis by Bacteroides fragilis in vivo and in vitro. Infect. Immun. 52: 488–492.Google Scholar
  10. 10.
    Rodloff, A. C. and Hahn, H., 1984, Synergistic lethality in experimental infections with Escherichia coli and Bacteroides fragilis. Zentralbi. Bakteriol. Mikrobiol. Hyg. A 258: 112–119.Google Scholar
  11. 11.
    Rodloff, A. C., Hilliger, F., Friedman, H. and Hahn, H., 1986, Effects of anti-Bacteroides-antibodies on Escherichia coli and different Bacteroides species in vitro and vivo. Zentralbl. Bakteriol. Mikrobiol. Hyg. A 262: 483–491.Google Scholar
  12. 12.
    Socransky, S. S. and Gibbons, R. J., 1965, Required role of Bacteroides melaninogenicus in mixed anaerobic infections. J. Infect. Dis. 115:. 247–253.Google Scholar
  13. 13.
    Weinstein, W. M., Onderdonk, A. B., Bartlett, J. G. and Gorbach, S. L., 1974, Experimental intra-abdominal abscesses in rats: development of an experimental model. Infect. Immun. 10: 1250–1255.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • A. C. Rodloff
    • 1
  • S. Ehlers
    • 1
  • D. K. Blanchard
    • 2
  • H. Hahn
    • 1
  1. 1.Institute for Medical Microbiology and ImmunologyFree University of BerlinFederal Republic of Germany
  2. 2.Department of Medical Microbiology and ImmunologyUniversity of South FloridaTampaUSA

Personalised recommendations