Endotoxin pp 585-588 | Cite as

Lipopolysaccharide, but Not Lethal Infection, Releases Tumor Necrosis Factor in Mice

  • R. D. Cornwell
  • D. T. Golenbock
  • R. A. Proctor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


An endogenously produced cytokine, tumor necrosis factor (TNF), is thought to be an important mediator in the pathophysiology of gram-negative sepsis (10). Infusions of TNF in animals reproduce the metabolic, hormonal, hemodynamic, and histopathologic finding seen in lethal gram-negative infection (7, 11). Pretreatment with polyclonal anti-TNF antibodies was shown to reduce endotoxin (LPS) lethality in mice (1). Passive immunization with monoclonal antibodies against recombinant human TNF conferred complete protection against shock and death in baboons challenged with an otherwise lethal infusion of E. coli (9). Measurable circulating levels of TNF have been found in animals following a lethal bolus infusion of LPS (2, 8) or live gram-negative bacteria (6, 9), while little has been reported concerning TNF produttion in other models of lethal gram-negative infection.


Tumor Necrosis Factor Passive Immunization Serum Tumor Necrosis Factor Recombinant Human Tumor Necrosis Factor Tumor Necrosis Factor Activity 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. D. Cornwell
    • 1
  • D. T. Golenbock
    • 1
  • R. A. Proctor
    • 1
  1. 1.Departments of Medicine and Medical MicrobiologyUniversity of WisconsinMadisonUSA

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