Abstract
In recent years, several reports have provided evidence for an involvement of the immune system during typhoid fever (3). In particular, a reduction of several immunological parameters such as leukocyte inhibiting factor (LIF) release, plaque-forming cell (PFC) production and natural killer (NK) cell activity have been demonstrated (1). In addition, Salmonella typhi organisms possess on their outermembrane the lipopolysaccharide (LPS) which is a powerful immunomodulating agent (4). Therefore, to better investigate the relationship between immune function and typhoid fever, we analyzed humoral and cell-mediated responses in typhoid patients towards LPS or whole bacteria.
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Antonaci, S., Garofalo, A. R., Stasi, D., Caretto, G., Jirilli, E. and Bonomo, L., 1987, Cell-mediated immunity in typhoid fever patients. Microbios Letters 35: 19.
Delia, S., Vullo, V., Mastroianni, C. M., Contini, C., Massetti, A. P., Cignarella, L. and Sorice, F., 1987, Use of dot immunobinding assay (DIB) for the rapid diagnosis of human brucellosis. J. Infection 14: 88.
Edelman, R. and Levine, M. M., 1986, Summary of an International Workshop of Typhoid Fever. Rev. Infect. Dis. 8: 329.
Galanos, C., Luderitz, O., Rietschel, E. T. and Westphal, 0., 1977, Newer aspects of the chemistry and biology of bacterial lipopolysaccharides, with special reference to their lipid A component, in: “International Review of Biochemistry. Biochemistry of lipids. II. Vol. 14,” T. W. Goodwin, ed., Baltimore, p. 239.
Tagliabue, A., Villa, L., Boraschi, D., Peri, G., De Gori, V. and Nencioni, L., 1985, Natural anti-bacterial activity against Salmonella typhi by human T4+ lymphocytes armed with IgA antibodies. J. Immunol. 135: 4178.
Vullo, V., Contini, C., Mastroianni, C. M., Massetti, A. P., Cignarella, L. and Delia, S., 1987, Evaluation of Dot Immunobinding Assay (DIB) for the Detection of Antibodies Against Brucella Melitensis, EOS Riv. Immunol. Immunopharmacol. 7: 147.
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Mastroianni, C.M., Misefari, A., Jirillo, E., De Simone, C., Vullo, V., Delia, S. (1990). Anti-LPS Region Antibody Responses and Cellular Immune Responsiveness in Typhoid Patients. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_52
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DOI: https://doi.org/10.1007/978-1-4757-5140-6_52
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