Endotoxin pp 567-579 | Cite as

A Study of the Cellular and Molecular Mediators of the Adjuvant Action of a Nontoxic Monophosphoryl Lipid A

  • A. G. Johnson
  • M. A. Tomai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


With the current resurgence of efforts to improve and expand human vaccines, attention is again being focused on the development of safe and effective adjuvants (17). In particular, the utilization of synthetic antigenic determinants or ligands of low molecular weight, which are inherently weak antigenically, necessitates the use of adjuvant carriers for optimum efficiency.


Spleen Cell Aging Mouse Antibody Formation Supernatant Fluid Peritoneal Exudate Cell 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • A. G. Johnson
    • 1
  • M. A. Tomai
    • 1
  1. 1.Department of Microbiology/Immunology, School of MedicineUniversity of MinnesotaDuluthUSA

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