Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?
Lipopolysaccharide (LPS) is an inducer of toxic and immunostimulatory or immunoregulatory responses (2). The lipid A moiety was shown to be the endotoxic principle of LPS (3, 9). Data about immunostimulatory properties like induction of interleukin 1 (IL-1) by LPS and lipid A are still conflicting. In this report LPS and partial structures thereof were used to define the structural element of LPS which is responsible for IL-1 induction. Evidence is given that lipid A is not only the endotoxic but also the major immunostimulatory and immunoregulatory principle of LPS.
KeywordsPartial Structure Induction Experiment Weak Inducer Dose Response Experiment Synthetic Lipid
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