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Endotoxin pp 561-566 | Cite as

Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?

  • H. Loppnow
  • I. Dürrbaum
  • H. Brade
  • C. A. Dinarello
  • S. Kusumoto
  • E. Th. Rietschel
  • H.-D. Flad
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Lipopolysaccharide (LPS) is an inducer of toxic and immunostimulatory or immunoregulatory responses (2). The lipid A moiety was shown to be the endotoxic principle of LPS (3, 9). Data about immunostimulatory properties like induction of interleukin 1 (IL-1) by LPS and lipid A are still conflicting. In this report LPS and partial structures thereof were used to define the structural element of LPS which is responsible for IL-1 induction. Evidence is given that lipid A is not only the endotoxic but also the major immunostimulatory and immunoregulatory principle of LPS.

Keywords

Partial Structure Induction Experiment Weak Inducer Dose Response Experiment Synthetic Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • H. Loppnow
    • 1
  • I. Dürrbaum
    • 2
  • H. Brade
    • 2
  • C. A. Dinarello
    • 1
  • S. Kusumoto
    • 3
  • E. Th. Rietschel
    • 2
  • H.-D. Flad
    • 2
  1. 1.Tufts University School of MedicineBostonUSA
  2. 2.Forschungsinstitut BorstelBorstelGermany
  3. 3.University of OsakaOsakaJapan

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